Systemic Inflammatory Response Syndrome (SIRS) Treatment Market
By Indication;
Meningitis, Urinary Tract Infection (UTI), Pneumonia, Hemorrhage, Autoimmune Diseases, and OthersBy Treatment Type;
Pharmacological Treatment and Non-Pharmacological TreatmentBy Route of Administration;
Oral Administration and Intravenous AdministrationBy End User;
Hospital & Clinics, Diagnostic Centers, Home Care, and OthersBy Geography;
North America, Europe, Asia Pacific, Middle East & Africa, and Latin America - Report Timeline (2021 - 2031)Systemic Inflammatory Response Syndrome (SIRS) Treatment Market Overview
Systemic Inflammatory Response Syndrome (SIRS) Treatment Market (USD Million)
Systemic Inflammatory Response Syndrome Treatment Market was valued at USD 14,344.82 million in the year 2024. The size of this market is expected to increase to USD 24,079.11 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 7.7%.
Systemic Inflammatory Response Syndrome (SIRS) Treatment Market
*Market size in USD million
CAGR 7.7 %
Study Period | 2025 - 2031 |
---|---|
Base Year | 2024 |
CAGR (%) | 7.7 % |
Market Size (2024) | USD 14,344.82 Million |
Market Size (2031) | USD 24,079.11 Million |
Market Concentration | Medium |
Report Pages | 384 |
Major Players
- CytoSorbents Corporation
- RegeneRx Biopharmaceuticals, Inc
- Endacea, Inc
- Adrenomed AG
- GlaxoSmithKline plc
- Asahi Kasei Corporation
- Cardinal Health
- Smith & Nephew plc
- ConvaTec, Inc.
- AstraZeneca
- Orion Corporation
- CHIESI Farmaceutici S.p.A
- Mylan N.V
Market Concentration
Consolidated - Market dominated by 1 - 5 major players
Systemic Inflammatory Response Syndrome (SIRS) Treatment Market
Fragmented - Highly competitive market without dominant players
The Systemic Inflammatory Response Syndrome (SIRS) Treatment Market is expanding steadily as healthcare providers focus on advanced therapeutic approaches to manage this severe condition. Triggered by infections, trauma, or medical complications, SIRS requires rapid intervention to reduce mortality risks. Currently, nearly 65% of critical care patients undergo treatment protocols addressing systemic inflammation, underscoring the market’s crucial role in intensive care.
Growing Demand for Critical Care Therapies
More than 55% of intensive care facilities have adopted specialized therapies for SIRS management. These approaches enhance patient monitoring, reduce complications, and improve recovery outcomes, positioning SIRS treatments as a core component of critical care strategies.
Advancements in Therapeutic Approaches
Innovations in drug formulations and immunomodulatory therapies are reshaping treatment standards. Around 40% of newly developed interventions target improved immune regulation and reduced inflammatory response, allowing faster stabilization and patient recovery. These advancements are driving demand for evidence-based solutions in systemic inflammation care.
Integration of Monitoring and Supportive Care
Nearly 50% of patients with SIRS require intensive monitoring and supportive interventions such as fluid management, respiratory support, and hemodynamic stabilization. The integration of advanced monitoring technologies ensures better real-time assessments, guiding precise therapeutic decisions and boosting clinical outcomes.
Rising Adoption Across Healthcare Facilities
Today, almost 60% of hospitals and specialized centers have implemented standardized SIRS management protocols. Their widespread adoption demonstrates the growing importance of comprehensive treatment pathways and highlights the market’s strong trajectory, supported by advances in critical care practices and innovative therapies.
Systemic Inflammatory Response Syndrome (SIRS) Treatment Market Recent Developments
- December 2022: Adoratherapy launched its Alkemie Chakra Healing collection, featuring aroma perfume sprays, dry touch body oils, body lotions, and lotion candles all with the same scents. The scents were formulated to balance and heal using aromatherapy principles, in which essential oils are active ingredients.
- October 2022: Coworth Park launched a new Hebridean sound treatment. Through the use of sound therapy, which is intended to be tranquil, relaxing, and transportive, the treatment provides a moment of rest and renewal.
Systemic Inflammatory Response Syndrome Treatment Market Segment Analysis
In this report, The Systemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By Indication, Treatment Type, Route of Administration, End User and Geography.
Systemic Inflammatory Response Syndrome Treatment Market, Segmentation by Indication
The Systemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By Indication into Meningitis, Urinary Tract Infection (UTI), Pneumonia, Hemorrhage, Autoimmune Diseases and Others.
Meningitis
Meningitis-related systemic inflammatory response cases require rapid diagnosis and treatment to prevent severe neurological damage. Common approaches include antibiotic therapy, corticosteroids, and supportive care, which can reduce mortality rates by 20–30%. This indication accounts for nearly 15–20% of the market, driven by the rising incidence of bacterial and viral meningitis globally.
Urinary Tract Infection (UTI)
UTI-triggered SIRS is often caused by severe or untreated infections leading to urosepsis. Treatment involves broad-spectrum antibiotics, intravenous fluids, and in some cases, vasopressor therapy. UTIs contribute to approximately 10–15% of SIRS cases, with elderly and immunocompromised populations at higher risk.
Pneumonia
Pneumonia-induced SIRS is a significant contributor to hospital admissions, particularly in patients with community-acquired and hospital-acquired pneumonia. Management includes targeted antimicrobial therapy and oxygen support, reducing complications by 15–25%. This segment represents around 20–25% of the overall market share.
Hemorrhage
Severe hemorrhage can trigger SIRS through tissue hypoxia and systemic inflammation. Treatment strategies involve blood transfusions, hemostatic agents, and critical care monitoring. Hemorrhage-related SIRS accounts for roughly 8–12% of cases, with high incidence in trauma and post-surgical patients.
Autoimmune Diseases
Autoimmune disorders such as lupus and rheumatoid arthritis can precipitate chronic systemic inflammation, leading to SIRS. Management includes immunosuppressive therapy, corticosteroids, and biologic agents. This segment contributes about 12–15% of the market, with growth driven by increased awareness and improved diagnostic capabilities.
Others
The “Others” category includes SIRS cases triggered by pancreatitis, burns, and severe allergic reactions. Treatment is largely supportive, focusing on stabilizing vital signs and addressing the underlying cause. These cases make up nearly 10–13% of the market, with prevalence linked to a wide range of acute health emergencies.
Systemic Inflammatory Response Syndrome Treatment Market, Segmentation by Treatment Type
The Systemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By Treatment Type into Pharmacological Treatment and Non-Pharmacological Treatment
Pharmacological Treatment
Pharmacological treatment for systemic inflammatory response syndrome primarily includes antibiotics, antiviral agents, anti-inflammatory drugs, and immunomodulators. These therapies aim to control the underlying cause, reduce inflammation, and prevent complications. Pharmacological interventions account for nearly 65–70% of the treatment approach due to their effectiveness in rapidly stabilizing patients and improving survival rates in both acute and chronic cases.
Non-Pharmacological Treatment
Non-pharmacological treatment focuses on supportive care measures such as fluid resuscitation, oxygen therapy, mechanical ventilation, and nutritional support. These methods help maintain organ function, manage symptoms, and enhance patient recovery. This segment represents about 30–35% of the market, with growing adoption in critical care units where comprehensive management strategies are essential for patient outcomes.
Systemic Inflammatory Response Syndrome Treatment Market, Segmentation by Route of Administration
The Systemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By Route of Administration into Oral Administration and Intravenous Administration
Oral Administration
Oral administration is widely used for managing mild to moderate systemic inflammatory response syndrome cases, offering convenience, cost-effectiveness, and patient compliance. It is suitable for long-term therapy and follow-up care, particularly in outpatient settings. This route accounts for approximately 35–40% of the market, driven by the availability of anti-inflammatory drugs and antibiotics in oral formulations.
Intravenous Administration
Intravenous administration is the preferred route for severe or acute SIRS cases, ensuring rapid drug delivery and immediate therapeutic action. It is commonly used in critical care units and emergency settings where quick intervention is vital. This segment dominates with nearly 60–65% market share due to its effectiveness in stabilizing patients and managing life-threatening conditions.
Systemic Inflammatory Response Syndrome Treatment Market, Segmentation by End User
The ystemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By End User into Hospital & Clinics, Diagnostic Centers, Home Care and Others.
Hospitals & Clinics
Hospitals and clinics are the primary end users for systemic inflammatory response syndrome treatment, accounting for nearly 55–60% of the market. They provide advanced diagnostic facilities, access to multidisciplinary care teams, and emergency response capabilities. Their role is critical in managing severe cases that require intensive care and continuous monitoring, leading to better patient outcomes.
Diagnostic Centers
Diagnostic centers contribute around 15–20% of the market, offering specialized testing services for early detection and monitoring of inflammatory markers. These facilities enable timely diagnosis and support treatment planning in collaboration with hospitals and clinics. The growing demand for quick and accurate laboratory results is boosting their market share.
Home Care
Home care services hold approximately 10–15% of the market, driven by the need for cost-effective post-discharge management and chronic condition monitoring. This segment is gaining traction among patients who prefer recovery in familiar surroundings, supported by telemedicine and remote monitoring technologies.
Others
The “Others” segment, representing about 5–10% of the market, includes rehabilitation centers, long-term care facilities, and research institutions. These settings play a supportive role in patient recovery, therapeutic innovation, and clinical studies, contributing to advancements in treatment strategies.
Systemic Inflammatory Response Syndrome Treatment Market, Segmentation by Geography
The Systemic Inflammatory Response Syndrome Treatment Market Has Been Segmented By Geography into five regions; North America, Europe, Asia Pacific, Middle East, Africa and Latin America.
Regions and Countries Analyzed in this Report
Systemic Inflammatory Response Syndrome Treatment Market Share (%), by Geographical Region
North America
North America leads the systemic inflammatory response syndrome treatment market with a share of around 40–45%, supported by advanced healthcare infrastructure, high awareness levels, and extensive adoption of advanced treatment protocols. The presence of leading pharmaceutical companies and strong reimbursement systems further enhance market growth in the region.
Europe
Europe accounts for nearly 25–30% of the market, driven by government healthcare initiatives, widespread availability of specialized care centers, and active research in critical care medicine. Collaborative healthcare networks across countries also strengthen access to timely diagnosis and treatment.
Asia Pacific
Asia Pacific is witnessing the fastest growth, with a market share of approximately 15–20% and a high projected CAGR. Factors such as increasing healthcare expenditure, rising incidence of infectious diseases, and growing investments in critical care facilities contribute to this rapid expansion.
Middle East & Africa
The Middle East & Africa region holds about 5–7% of the market, supported by government-led healthcare improvements and gradual adoption of modern treatment approaches. However, disparities in infrastructure between urban and rural areas continue to impact growth potential.
Latin America
Latin America represents roughly 5–8% of the market, with growth driven by public health programs, expansion of critical care units, and increased awareness of early SIRS management. Countries like Brazil, Mexico, and Argentina are leading in implementing advanced care protocols.
Market Trends
This report provides an in depth analysis of various factors that impact the dynamics of Global Systemic Inflammatory Response Syndrome Treatment Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.
Drivers, Restraints and Opportunity Analysis
Drivers:
- Aging Population and Chronic Diseases
- Growing Awareness and Diagnosis Rates
- Rise in Surgical Procedures and Traumatic Injuries
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Emerging Therapeutic Approaches and Drug Development: Emerging therapeutic approaches and drug development for the treatment of Global Systemic Inflammatory Response Syndrome (SIRS) represent a crucial frontier in modern medicine. SIRS, characterized by a dysregulated systemic inflammatory response, often arises as a severe complication of various conditions such as sepsis, trauma, or severe infections. Given its complex pathophysiology and potentially life-threatening consequences, there is an urgent need for innovative treatment modalities. One promising avenue involves the development of targeted immunomodulatory therapies aimed at restoring immune balance and attenuating the hyperinflammatory response associated with SIRS. These therapies may include biologics targeting specific cytokines or signaling pathways implicated in the pathogenesis of SIRS, as well as novel small molecules designed to modulate immune cell function.
Advancements in precision medicine and personalized therapy hold great promise for optimizing treatment outcomes in SIRS patients. By leveraging techniques such as genomic profiling and biomarker analysis, clinicians can identify individuals who are most likely to benefit from specific therapies and tailor treatment regimens accordingly. This approach not only enhances therapeutic efficacy but also minimizes the risk of adverse effects associated with broad-spectrum immunosuppression. The integration of cutting-edge technologies such as artificial intelligence and machine learning into drug discovery and development processes has the potential to accelerate the identification of novel therapeutic targets and facilitate the design of more effective interventions for SIRS.
The collaborative efforts of academia, industry, and regulatory agencies are essential for driving innovation and expediting the translation of promising preclinical findings into clinically viable therapies for SIRS. Robust preclinical models that recapitulate the complex pathophysiology of SIRS are instrumental for elucidating disease mechanisms and evaluating the efficacy of investigational treatments. Streamlined regulatory pathways and incentives for orphan drug development can incentivize investment in SIRS research and incentivize pharmaceutical companies to prioritize the development of novel therapies for this underserved patient population. By fostering a collaborative and multidisciplinary approach to drug development, the medical community can address the unmet clinical needs of SIRS patients and improve outcomes in this critically ill population.
Restraints:
- Government Initiatives and Funding Support
- Strategic Collaborations and Partnerships in Research
- Shift towards Personalized Medicine and Precision Therapeutics
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Favorable Reimbursement Policies and Healthcare Infrastructure: Favorable reimbursement policies play a pivotal role in shaping the landscape of healthcare markets, especially in the treatment of complex conditions like systemic inflammatory response syndrome (SIRS). Robust reimbursement policies can significantly alleviate the financial burden on patients and healthcare providers, ensuring access to necessary treatments without undue financial strain. Governments and insurance companies that implement reimbursement schemes covering a substantial portion of SIRS treatment costs not only enhance patient outcomes but also stimulate market growth by encouraging investment in research, development, and innovation. Transparent and efficient reimbursement processes foster confidence among healthcare stakeholders, promoting the adoption of advanced therapies and technologies for SIRS management.
A well-developed healthcare infrastructure forms the backbone of effective SIRS treatment, encompassing a spectrum of facilities, services, and professionals essential for diagnosis, treatment, and ongoing care. Investment in healthcare infrastructure, including hospitals, clinics, laboratories, and specialized treatment centers, enhances the accessibility and quality of SIRS treatment, particularly in underserved regions. An integrated healthcare system that facilitates seamless coordination among various healthcare entities ensures timely and comprehensive care for SIRS patients, optimizing treatment outcomes and reducing healthcare disparities. Advanced healthcare infrastructure equipped with state-of-the-art medical technologies and skilled healthcare personnel enables the implementation of personalized treatment approaches tailored to individual patient needs, driving advancements in SIRS management and improving overall patient prognosis.
In the global systemic inflammatory response syndrome (SIRS) treatment market, favorable reimbursement policies and robust healthcare infrastructure synergistically contribute to market growth and sustainability. Countries with well-established healthcare systems and supportive reimbursement frameworks witness heightened investment and innovation in SIRS treatment modalities, fostering market expansion and driving technological advancements. Proactive government initiatives aimed at improving healthcare infrastructure, coupled with strategic partnerships between public and private sectors, bolster the capacity to effectively manage SIRS cases and mitigate associated morbidity and mortality rates. By addressing both financial barriers through reimbursement policies and logistical challenges through healthcare infrastructure development, stakeholders can collaboratively work towards advancing SIRS treatment options, ultimately improving patient outcomes and promoting population health.
Opportunities:
- Clinical Uncertainties
- Resource Constraints
- Technological Limitations
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Cultural and Societal Factors: The treatment market for Global Systemic Inflammatory Response Syndrome (SIRS) is deeply influenced by cultural and societal factors across the globe. Varying cultural perceptions of healthcare and illness significantly impact the adoption and acceptance of treatment options. In some cultures, there may be a preference for traditional or alternative medicine over conventional Western treatments, affecting the demand and utilization of SIRS therapies. Cultural norms surrounding communication with healthcare providers, decision-making processes within families, and stigma associated with certain illnesses can influence the seeking of treatment and adherence to prescribed therapies.
Socioeconomic factors play a pivotal role in shaping the SIRS treatment market. Disparities in income, education, and access to healthcare resources create significant barriers to effective treatment. In regions with limited healthcare infrastructure or insurance coverage, accessing specialized therapies for SIRS can be challenging, leading to unequal distribution of healthcare services and outcomes. Societal attitudes towards healthcare financing and government involvement in healthcare provision impact the availability and affordability of SIRS treatments, shaping market dynamics and patient access.
The prevalence of SIRS risk factors such as obesity, smoking, and sedentary lifestyles varies across cultures and societies, influencing the demand for treatment options. Cultural norms around diet, exercise, and preventive healthcare practices affect the incidence and severity of SIRS-related conditions, driving the need for interventions and therapeutics. Societal attitudes towards risk perception, health literacy, and preventive care behaviors impact the effectiveness of public health initiatives aimed at reducing SIRS incidence and improving treatment outcomes. Understanding these cultural and societal factors is crucial for developing tailored strategies to address the diverse needs of SIRS patients worldwide and optimize the global treatment market.
Competitive Landscape Analysis
Key players in Global Systemic Inflammatory Response Syndrome Treatment Market include:
- CytoSorbents Corporation
- RegeneRx Biopharmaceuticals, Inc
- Endacea, Inc
- Adrenomed AG
- GlaxoSmithKline plc
- Asahi Kasei Corporation
- Cardinal Health
- Smith & Nephew plc
- ConvaTec, Inc.
- AstraZeneca
- Orion Corporation
- CHIESI Farmaceutici S.p.A
- Mylan N.V
In this report, the profile of each market player provides following information:
- Company Overview and Product Portfolio
- Key Developments
- Financial Overview
- Strategies
- Company SWOT Analysi
- Introduction
- Research Objectives and Assumptions
- Research Methodology
- Abbreviations
- Market Definition & Study Scope
- Executive Summary
- Market Snapshot, By Indication
- Market Snapshot, By Treatment Type
- Market Snapshot, By Route of Administration
- Market Snapshot, By End User
- Market Snapshot, By Region
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Systemic Inflammatory Response Syndrome (SIRS) Treatment Market Dynamics
- Drivers, Restraints and Opportunities
- Drivers
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Aging Population and Chronic Diseases
-
Growing Awareness and Diagnosis Rates
-
Rise in Surgical Procedures and Traumatic Injuries
-
Emerging Therapeutic Approaches and Drug Development
-
- Restraints
-
Government Initiatives and Funding Support
-
Strategic Collaborations and Partnerships in Research
-
Shift towards Personalized Medicine and Preision Therapeutics
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Favorable Reimbursement Policies and Healthcare Infrastructure
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- Opportunities
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Clinical Uncertainties
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Resource Constraints
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Technological Limitations
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Cultural and Societal Factors
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- Drivers
- PEST Analysis
- Political Analysis
- Economic Analysis
- Social Analysis
- Technological Analysis
- Porter's Analysis
- Bargaining Power of Suppliers
- Bargaining Power of Buyers
- Threat of Substitutes
- Threat of New Entrants
- Competitive Rivalry
- Drivers, Restraints and Opportunities
- Market Segmentation
- Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, By Indication, 2021 - 2031 (USD Million)
- Hospital & Clinics
- Diagnostic Centers
- Home Care
- Others
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Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, By Treatment Type, 2021 - 2031 (USD Million)
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Pharmacological Treatment
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Non-Pharmacological Treatment
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Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, By Route of Administration, 2021 - 2031 (USD Million)
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Oral Administration
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Intravenous Administration
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- Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, Market, By End User, 2021 - 2031 (USD Million)
- Meningitis
- Urinary Tract Infection (UTI)
- Pneumonia
- Hemorrhage
- Autoimmune Diseases
- Others
- Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, By Geography, 2021 - 2031 (USD Million)
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North America
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United States
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Canada
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Europe
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Germany
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United Kingdom
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France
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Italy
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Spain
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Nordic
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Benelux
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Rest of Europe
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Asia Pacific
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Japan
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China
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India
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Australia & New Zealand
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South Korea
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ASEAN (Association of South East Asian Countries)
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Rest of Asia Pacific
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Middle East & Africa
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GCC
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Israel
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South Africa
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Rest of Middle East & Africa
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Latin America
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Brazil
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Mexico
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Argentina
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Rest of Latin America
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- Systemic Inflammatory Response Syndrome (SIRS) Treatment Market, By Indication, 2021 - 2031 (USD Million)
- Competitive Landscape
- Company Profiles
- CytoSorbents Corporation
- RegeneRx Biopharmaceuticals, Inc
- Endacea, Inc
- Adrenomed AG
- GlaxoSmithKline plc
- Asahi Kasei Corporation
- Cardinal Health
- Smith & Nephew plc
- ConvaTec, Inc.
- AstraZeneca
- Orion Corporation
- CHIESI Farmaceutici S.p.A
- Mylan N.V
- Company Profiles
- Analyst Views
- Future Outlook of the Market