Restless Legs Syndrome Market

By Type;

Primary Restless Legs Syndrome and Secondary Restless Legs Syndrome

By Route of Administration;

Oral and Injectable

By Treatment Type;

Medication & Devices, Dopamine Agonists, Anti-Seizure Agent, Benzodiazepines, Opioids, and Others

By Distribution Channel;

Hospital Pharmacy, Retail Pharmacy, and Online Pharmacy

By Geography;

North America, Europe, Asia Pacific, Middle East & Africa, and Latin America - Report Timeline (2021 - 2031).
Report ID: Rn154741157 Published Date: August, 2025 Updated Date: September, 2025

Restless Legs Syndrome Market Overview

Restless Legs Syndrome Market (USD Million)

Restless Legs Syndrome Market was valued at USD 2193.81 million in the year 2024. The size of this market is expected to increase to USD 3086.91 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 5.0%.


Restless Legs Syndrome Market

*Market size in USD million

CAGR 5.0 %


Study Period2025 - 2031
Base Year2024
CAGR (%)5.0 %
Market Size (2024)USD 2193.81 Million
Market Size (2031)USD 3086.91 Million
Market ConcentrationMedium
Report Pages343
2193.81
2024
3086.91
2031

Major Players

  • GlaxoSmithKline plc
  • UCB S.A.
  • Pfizer Inc.
  • Merck & Co., Inc.
  • Boehringer Ingelheim International GmbH
  • Sanofi S.A.
  • Teva Pharmaceutical Industries Ltd.
  • Jazz Pharmaceuticals plc
  • Sun Pharmaceutical Industries Ltd.
  • Mylan N.V.

Market Concentration

Consolidated - Market dominated by 1 - 5 major players

Restless Legs Syndrome Market

Fragmented - Highly competitive market without dominant players


The Restless Legs Syndrome Market is gaining traction as awareness of the condition rises. Affecting ~8–10% of adults, nearly 35% experience symptoms on 3+ nights per week and around 45% report a quality-of-life decline. With ~60% of cases linked to sleep disruption, improved detection—growing by ~20–25%—is pushing demand for durable and better-tolerated therapies.

Unmet Need & Diagnosis
Despite progress, an underdiagnosis gap of ~50–60% persists. Around 40% of treated patients report suboptimal control, particularly those with moderate-to-severe disease spanning ~30–40% of cases. Dissatisfaction above ~45% is fueling interest in long-acting solutions with reduced augmentation risk, highlighting a critical space for therapeutic innovation.

Therapeutic Landscape
Current treatment relies heavily on dopaminergic and α2-δ therapies, with exposure near 70%. However, 20–25% of patients switch due to adverse events and augmentation. Integration of iron repletion and non-drug interventions reaches ~30%, supporting holistic care. Meanwhile, once-daily and extended-release profiles attract ~55% of prescribers seeking regimen simplicity.

Digital Care & Monitoring
The digital shift is transforming patient management, with wearables and actigraphy used in ~25–30% of sleep assessments to provide objective metrics. Telehealth supports ~40% of follow-ups, boosting persistence by ~15–20% through structured coaching. Programs combining behavioral sleep support deliver ~30% gains in adherence and routine stabilization.

  1. Introduction
    1. Research Objectives and Assumptions
    2. Research Methodology
    3. Abbreviations
  2. Market Definition & Study Scope
  3. Executive Summary
    1. Market Snapshot, By Type
    2. Market Snapshot, By Route of Administration
    3. Market Snapshot, By Treatment Type
    4. Market Snapshot, By Distribution Channel
    5. Market Snapshot, By Region
  4. Restless Legs Syndrome Market Dynamics
    1. Drivers, Restraints and Opportunities
      1. Drivers
        1. Advancements in medical research and technology
        2. Increasing awareness and diagnosis of restless legs syndrome
      2. Restraints
        1. Side effects associated with current treatments
        2. Limited understanding of the underlying causes of restless legs syndrome
      3. Opportunities
        1. Development of novel therapeutics and treatment options
        2. Growing demand for effective management of restless legs syndrome symptoms
    2. PEST Analysis
      1. Political Analysis
      2. Economic Analysis
      3. Social Analysis
      4. Technological Analysis
    3. Porter's Analysis
      1. Bargaining Power of Suppliers
      2. Bargaining Power of Buyers
      3. Threat of Substitutes
      4. Threat of New Entrants
      5. Competitive Rivalry
  5. Market Segmentation
    1. Restless Legs Syndrome Market, By Type, 2021 - 2031 (USD Million)
      1. Primary Restless Legs Syndrome
      2. Secondary Restless Legs Syndrome
    2. Restless Legs Syndrome Market, By Route of Administration, 2021 - 2031 (USD Million)
      1. Oral
      2. Injectable
    3. Restless Legs Syndrome Market, By Treatment Type, 2021 - 2031 (USD Million)
      1. Medication & Devices
      2. Dopamine Agonists
      3. Anti-Seizure Agent
      4. Benzodiazepines
      5. Opioids
      6. Others
    4. Restless Legs Syndrome Market, By Distribution Channel, 2021 - 2031 (USD Million)
      1. Hospital Pharmacy
      2. Retail Pharmacy
      3. Online Pharmacy
    5. Restless Legs Syndrome Market, By Geography, 2021 - 2031 (USD Million)
      1. North America
        1. United States
        2. Canada
      2. Europe
        1. Germany
        2. United Kingdom
        3. France
        4. Italy
        5. Spain
        6. Nordic
        7. Benelux
        8. Rest of Europe
      3. Asia Pacific
        1. Japan
        2. China
        3. India
        4. Australia & New Zealand
        5. South Korea
        6. ASEAN (Association of South East Asian Countries)
        7. Rest of Asia Pacific
      4. Middle East & Africa
        1. GCC
        2. Israel
        3. South Africa
        4. Rest of Middle East & Africa
      5. Latin America
        1. Brazil
        2. Mexico
        3. Argentina
        4. Rest of Latin America
  6. Competitive Landscape
    1. Company Profiles
      1. GlaxoSmithKline plc
      2. UCB S.A.
      3. Pfizer Inc.
      4. Merck & Co., Inc.
      5. Boehringer Ingelheim International GmbH
      6. Sanofi S.A.
      7. Teva Pharmaceutical Industries Ltd.
      8. Jazz Pharmaceuticals plc
      9. Sun Pharmaceutical Industries Ltd.
      10. Mylan N.V.
  7. Analyst Views
  8. Future Outlook of the Market