Global Oligonucleotide Synthesis Market Growth, Share, Size, Trends and Forecast (2025 - 2031)
By Product;
Drugs, Synthesized Oligo, Reagents, and Equipment.By Type;
Custom, and Predesigned.By Application;
Therapeutic Applications, Diagnostics, Research, and Others.By End User;
Academic Research Institutes, Pharmaceutical and Biotechnology Companies, Diagnostic Laboratories, and Others.By Geography;
North America, Europe, Asia Pacific, Middle East and Africa, and Latin America - Report Timeline (2021 - 2031).Introduction
Global Oligonucleotide Synthesis Market (USD Million), 2021 - 2031
In the year 2023, the Global Oligonucleotide Synthesis Market was valued at USD 4,554.40 million. The size of this market is expected to increase to USD 10,290.64 million by the year 2030, while growing at a Compounded Annual Growth Rate (CAGR) of 12.4%.
Oligonucleotides, short sequences of nucleotides, are pivotal in genetic testing, molecular diagnostics, and drug development. The surge in demand for personalized medicine, alongside advances in biotechnology and genomics, has significantly bolstered the market. With the increasing prevalence of genetic disorders and chronic diseases, there is a heightened need for precise and reliable diagnostic tools, further propelling the market forward. The advent of innovative technologies such as CRISPR-Cas9 and next-generation sequencing has revolutionized genetic research, leading to a higher demand for custom oligonucleotides.
Pharmaceutical and biotechnological companies are heavily investing in oligonucleotide-based therapies, including antisense oligonucleotides, small interfering RNAs (siRNAs), and aptamers, to address a wide range of medical conditions, from rare genetic diseases to cancer. Additionally, the rise of synthetic biology and the growing interest in synthetic genes and genome editing are contributing to the market's expansion. The continuous advancements in oligonucleotide synthesis technologies have resulted in higher purity, better accuracy, and faster synthesis processes, making these vital molecules more accessible and cost-effective.
Global Oligonucleotide Synthesis Market Recent Developments
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In November 2023, LCG Biosearch Technologies, a unit of LGC Limited, acquired PolyDesign to enhance its oligonucleotide synthesis capabilities. This acquisition enabled LCG to leverage PolyDesign's frit technology, improving the efficiency and quality of its oligonucleotide production processes.
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In October 2023, Integrated DNA Technologies (IDT), a subsidiary of Danaher Corporation, opened its therapeutic oligonucleotide manufacturing facility in Coralville, Iowa. This facility produced reagents for cGMP cell and gene therapy, including single-guide RNAs and HDR donor oligos, enhancing biopharmaceutical capabilities.
Segment Analysis
The Global Oligonucleotide Synthesis Market is segmented by product, with the key categories being custom oligonucleotides, pre-designed oligonucleotides, and reagents and consumables. Custom oligonucleotides are tailored to meet specific research needs, making them the most significant product category in the market. These are used in a wide range of applications, including gene sequencing, PCR amplification, and gene editing, and are highly demanded by researchers and pharmaceutical companies. Pre-designed oligonucleotides, which are commercially available and standardized, are commonly used in diagnostic applications and routine research. The reagents and consumables segment includes essential chemicals and materials required for oligonucleotide synthesis, further fueling the market growth, as they support the ongoing production and use of synthesized oligonucleotides in various laboratories.
In terms of type, the market can be divided into DNA oligonucleotides and RNA oligonucleotides. DNA oligonucleotides dominate the market, as they are widely used in numerous applications, such as DNA sequencing, PCR, and gene synthesis. The increasing prevalence of genetic disorders, the rise of personalized medicine, and the growing demand for DNA-based diagnostic tools are major drivers for the demand for DNA oligonucleotides. RNA oligonucleotides, on the other hand, are increasingly gaining attention due to their pivotal role in gene expression studies, RNA interference (RNAi) therapies, and antisense oligonucleotide (ASO) drugs. The development of RNA-based therapeutics and vaccines, such as mRNA vaccines, has accelerated the demand for RNA oligonucleotides, leading to strong growth in this segment.
The application segment in the oligonucleotide synthesis market includes therapeutics, diagnostics, research, and others. The therapeutic applications are one of the largest and fastest-growing segments, driven by the development of oligonucleotide-based drugs for diseases like cancer, genetic disorders, and viral infections. Diagnostics applications, particularly in molecular diagnostics, are also experiencing growth due to the rising demand for precise and early-stage diagnostic techniques using PCR, NGS, and other molecular biology techniques. Research remains a crucial application area, with oligonucleotides used extensively in gene editing, genetic research, and functional genomics. The end-user segmentation includes academic research institutes, pharmaceutical and biotechnology companies, diagnostic laboratories, and others, with academic institutes and pharmaceutical companies being the leading users of synthesized oligonucleotides. Geographically, the market is seeing robust growth in regions like North America and Europe, where advanced healthcare systems and strong research infrastructures are prevalent. Meanwhile, the Asia-Pacific region is experiencing rapid growth due to expanding healthcare access, increased research initiatives, and rising biotech investments.
Global Oligonucleotide Synthesis Segment Analysis
In this report, the Global Oligonucleotide Synthesis Market has been segmented by Product, Type, Application, End User and Geography.
Global Oligonucleotide Synthesis Market, Segmentation by Product
The Global Oligonucleotide Synthesis Market has been segmented by Product into Drugs, Synthesized Oligo, Reagents and Equipment.
Drugs constitute a significant segment within the market, encompassing oligonucleotide-based therapeutics designed to target specific genes or gene products implicated in various diseases. These drugs include antisense oligonucleotides, small interfering RNAs (siRNAs), and aptamers, among others, which hold promise for treating a wide range of medical conditions, including genetic disorders, viral infections, and cancer.
Synthesized oligonucleotides represent another key product category, comprising custom-made sequences synthesized to precise specifications for specific applications in molecular biology, genetic testing, and diagnostics. These synthesized oligonucleotides serve as essential tools in techniques such as polymerase chain reaction (PCR), DNA sequencing, and gene editing, facilitating research and development across academic, industrial, and clinical settings.
Reagents constitute an indispensable component of oligonucleotide synthesis workflows, encompassing a variety of chemicals, enzymes, and buffers required for oligonucleotide synthesis, purification, and modification.
Global Oligonucleotide Synthesis Market, Segmentation by Type
The Global Oligonucleotide Synthesis Market has been segmented by Type into Custom and Predesigned.
Custom oligonucleotides represent a versatile and highly customizable category of products, synthesized to precise specifications based on the unique needs of individual researchers, laboratories, or projects. These custom oligonucleotides offer flexibility in sequence design, length, modifications, and purification methods, allowing researchers to tailor them for specific applications such as PCR primer design, gene synthesis, or targeted sequencing. Custom oligonucleotides are particularly valuable in research settings where precise control over sequence composition and functionality is essential for experimental success.
Predesigned oligonucleotides constitute a preselected catalog of sequences designed for common applications or research targets. These predesigned oligonucleotides offer convenience and time savings by providing readily available solutions for standard molecular biology techniques, gene expression assays, or diagnostic tests.
Predesigned oligonucleotides are often optimized for performance and compatibility with popular experimental protocols, making them suitable for routine laboratory workflows and high-throughput applications.
Global Oligonucleotide Synthesis Market, Segmentation by Application
The Global Oligonucleotide Synthesis Market has been segmented by Application into Therapeutic Applications, Diagnostics, Research and Others.
The Global Oligonucleotide Synthesis Market is experiencing significant growth, with various applications driving its expansion. One of the largest segments is therapeutic applications, which includes the use of synthesized oligonucleotides in the development of novel therapies for a wide range of diseases. These applications span areas such as gene therapy, antisense oligonucleotide therapies, and RNA interference (RNAi) technologies. Oligonucleotides are used to target specific genetic sequences, enabling the treatment of genetic disorders, cancers, and viral infections. The increasing focus on personalized medicine and the growing pipeline of oligonucleotide-based drugs are expected to further propel the demand in this segment, making therapeutic applications a major driver of the market.
Diagnostics is another key application driving the growth of the oligonucleotide synthesis market. Oligonucleotides are widely used in diagnostic tests, particularly in molecular diagnostics, where they function as probes or primers in techniques like PCR (polymerase chain reaction), next-generation sequencing (NGS), and in situ hybridization. These techniques allow for the detection of genetic mutations, bacterial and viral infections, and cancer biomarkers, among other applications. As the demand for precise, early-stage diagnostics continues to rise, the use of oligonucleotides in molecular diagnostics is expanding, with significant growth expected in areas like infectious disease testing and oncology diagnostics.
Research is also a major contributor to the oligonucleotide synthesis market, particularly in the fields of genomics and molecular biology. Oligonucleotides play a pivotal role in research applications, including gene expression analysis, DNA sequencing, and gene editing technologies such as CRISPR. Researchers rely on synthesized oligonucleotides to design specific DNA or RNA sequences for various experimental purposes, advancing our understanding of genetics, disease mechanisms, and drug development. In addition, the increasing demand for oligonucleotides in functional genomics and the rising trend of biotech and pharmaceutical research further strengthen the role of this segment in the market. The others category includes additional applications in areas such as agriculture, biotechnology, and forensic science, where oligonucleotides are used for genetic analysis and molecular testing, contributing to the overall growth of the oligonucleotide synthesis market.
Global Oligonucleotide Synthesis Market, Segmentation by End User
The Global Oligonucleotide Synthesis Market has been segmented by End User into Academic Research Institutes, Pharmaceutical and Biotechnology Companies, Diagnostic Laboratories and Others.
The Global Oligonucleotide Synthesis Market is segmented by end user, with academic research institutes being one of the largest segments. Academic institutions play a crucial role in the development and advancement of oligonucleotide-based technologies, as they conduct cutting-edge research in genomics, molecular biology, and biotechnology. These institutions require a steady supply of oligonucleotides for applications such as gene expression analysis, PCR, DNA sequencing, and gene editing. The growing focus on personalized medicine and genomic research further drives the demand for synthesized oligonucleotides in these settings. With the increasing availability of advanced sequencing technologies and the expanding field of functional genomics, academic research institutes are expected to continue being significant contributors to the market.
Pharmaceutical and biotechnology companies are another key end user segment in the oligonucleotide synthesis market. These companies use oligonucleotides extensively in drug discovery, development, and manufacturing, particularly in the creation of novel oligonucleotide-based therapeutics, such as antisense oligonucleotides and gene-editing tools like CRISPR. The rise in precision medicine and the increasing number of clinical trials investigating oligonucleotide-based treatments for diseases such as cancer, genetic disorders, and viral infections are expected to fuel the demand for synthesized oligonucleotides in this segment. Pharmaceutical and biotechnology companies also rely on oligonucleotides for biomarker discovery, target validation, and personalized drug development, further driving the growth of this segment in the market.
Diagnostic laboratories represent another significant end user group within the oligonucleotide synthesis market. These laboratories use oligonucleotides in various diagnostic applications, such as PCR, sequencing, and in situ hybridization, to detect genetic disorders, infectious diseases, and cancer. The increasing demand for molecular diagnostic techniques, driven by the need for rapid and accurate disease detection, is propelling the use of oligonucleotides in this sector. Moreover, the growing prevalence of chronic and infectious diseases, along with advancements in point-of-care diagnostics, is expected to further increase the adoption of oligonucleotide-based diagnostic methods. The others category includes additional end users such as contract research organizations (CROs), forensic labs, and agricultural biotech firms, where oligonucleotides are used in genetic testing, environmental monitoring, and crop improvement research. These diverse applications contribute to the overall growth of the oligonucleotide synthesis market.
Global Oligonucleotide Synthesis Market, Segmentation by Geography
In this report, the Global Oligonucleotide Synthesis Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East and Africa and Latin America.
Global Oligonucleotide Synthesis Market Share (%), by Geographical Region, 2024
North America emerges as a dominant market for oligonucleotide synthesis, primarily led by the United States. The region boasts a robust biotechnology sector, advanced research infrastructure, and a favorable regulatory environment, fostering innovation and driving market growth. The presence of key industry players, academic institutions, and research organizations further accelerates the adoption of oligonucleotide-based technologies in various applications, including drug discovery, diagnostics, and personalized medicine.
Europe constitutes another significant market for oligonucleotide synthesis, characterized by increasing investments in genomic research, biopharmaceutical development, and precision medicine initiatives. Countries such as the United Kingdom, Germany, and Switzerland are at the forefront of technological innovation, driving demand for custom oligonucleotides and advanced synthesis platforms.
Asia Pacific emerges as a rapidly growing market fueled by expanding biopharmaceutical industry, rising healthcare expenditure, and growing emphasis on personalized medicine across countries like China, Japan, and India. The region presents lucrative opportunities for market players, supported by government initiatives, research collaborations, and increasing adoption of oligonucleotide-based therapies in the region's burgeoning healthcare landscape.
Market Trends
This report provides an in depth analysis of various factors that impact the dynamics of Global Oligonucleotide Synthesis Market. These factors include; Market Drivers, Restraints and Opportunities.
Drivers, Restraints and Opportunity Analysis
Drivers
- Advancements in Biotechnology and Genomics
- Growing Demand for Personalized Medicine
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Increasing Prevalence of Genetic Disorders and Chronic Diseases - Genetic disorders, encompassing a broad spectrum of inherited conditions resulting from abnormalities in an individual's genome, pose a substantial healthcare burden worldwide. These disorders can manifest across various organ systems and encompass diverse pathologies, ranging from rare genetic syndromes to more prevalent conditions such as cystic fibrosis, muscular dystrophy, and Huntington's disease.
Chronic diseases, including cardiovascular diseases, diabetes, cancer, and neurological disorders, represent a global epidemic, contributing to a significant proportion of morbidity and mortality worldwide. Many chronic diseases have underlying genetic components or are influenced by genetic predispositions, environmental factors, and lifestyle choices. As such, there is a growing recognition of the importance of understanding the genetic basis of these diseases for early diagnosis, risk assessment, and personalized treatment strategies.
Oligonucleotide synthesis plays a pivotal role in addressing the diagnostic and therapeutic challenges posed by genetic disorders and chronic diseases. Custom-designed oligonucleotides serve as indispensable tools for genetic testing, enabling the detection of disease-causing mutations, polymorphisms, and gene expression patterns. Furthermore, oligonucleotide-based technologies, such as antisense oligonucleotides, RNA interference (RNAi), and gene editing tools like CRISPR-Cas9, offer promising avenues for therapeutic intervention.
Restraints
- High Cost of Oligonucleotide Synthesis
- Stringent Regulatory Requirements
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Limited Adoption in Developing Regons - One of the primary barriers to adoption is the lack of access to advanced biotechnology infrastructure and expertise in many developing countries. Oligonucleotide synthesis requires specialized equipment, reagents, and skilled personnel, which may be scarce or unavailable in resource-constrained settings. Additionally, limited investment in research and development infrastructure hampers the capacity of academic institutions, research organizations, and biotechnology companies in these regions to innovate and adopt cutting-edge oligonucleotide technologies.
Regulatory complexities and stringent quality control requirements present formidable hurdles for market entry and product commercialization in developing regions. Oligonucleotide-based products are subject to rigorous regulatory scrutiny and approval processes, which vary across countries and regions. Navigating these regulatory landscapes demands significant time, resources, and expertise, posing challenges for manufacturers and distributors seeking to penetrate emerging markets.
Opportunities
- Rising Investment in Oligonucleotide-Based Therapies
- Technological Innovations in Synthesis Processes
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Expansion of Synthetic Biology and Genome Editing Applications - One of the key opportunities lies in the development of novel therapeutic modalities enabled by oligonucleotide-based genome editing technologies such as CRISPR-Cas9. These technologies offer unprecedented precision and efficiency in modifying DNA sequences, holding immense promise for treating genetic diseases, cancer, and infectious diseases. Oligonucleotides play pivotal roles as guide RNAs, donor templates, and delivery vehicles in CRISPR-mediated genome editing approaches, facilitating targeted genetic modifications with high specificity and minimal off-target effects.
The expansion of synthetic biology applications beyond traditional biomedicine presents new avenues for oligonucleotide synthesis. In industrial biotechnology, synthetic biology techniques are utilized to engineer microorganisms for the production of biofuels, chemicals, and pharmaceuticals. Oligonucleotides play critical roles in gene synthesis, pathway engineering, and gene regulation, enabling the design and optimization of microbial strains with enhanced metabolic capabilities and productivity.
Another emerging opportunity lies in the convergence of synthetic biology with fields such as agriculture, environmental biotechnology, and bioinformatics. Oligonucleotide-based technologies are instrumental in engineering crops with improved traits, developing biosensors for environmental monitoring, and designing computational models for predictive biology. The integration of machine learning and automation technologies with oligonucleotide synthesis workflows holds the potential to accelerate innovation and streamline the design-build-test cycle in synthetic biology research and development.
Competitive Landscape Analysis
Key players in Global Oligonucleotide Synthesis Market include:
- Danaher Corporation
- Thermo Fisher Scientific Inc
- Merck KGaA
- Eurofins Scientific
- LGC Limited
- Agilent Technologies Inc
- Kaneka Corporation
- Maravai Lifesciences Holdings Inc
- Azenta Inc
In this report, the profile of each market player provides following information:
- Company Overview and Product Portfolio
- Key Developments
- Financial Overview
- Strategies
- Company SWOT Analysis
- Introduction
- Research Objectives and Assumptions
- Research Methodology
- Abbreviations
- Market Definition & Study Scope
- Executive Summary
- Market Snapshot, By Product
- Market Snapshot, By Type
- Market Snapshot, By Application
- Market Snapshot, By End User
- Market Snapshot, By Region
- Global Oligonucleotide Synthesis Market Dynamics
- Drivers, Restraints and Opportunities
- Drivers
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Advancements in Biotechnology and Genomics
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Growing Demand for Personalized Medicine
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Increasing Prevalence of Genetic Disorders and Chronic Diseases
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- Restraints
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High Cost of Oligonucleotide Synthesis
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Stringent Regulatory Requirements
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Limited Adoption in Developing Regions
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- Opportunities
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Rising Investment in Oligonucleotide-Based Therapies
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Technological Innovations in Synthesis Processes
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Expansion of Synthetic Biology and Genome Editing Applications
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- Drivers
- PEST Analysis
- Political Analysis
- Economic Analysis
- Social Analysis
- Technological Analysis
- Porter's Analysis
- Bargaining Power of Suppliers
- Bargaining Power of Buyers
- Threat of Substitutes
- Threat of New Entrants
- Competitive Rivalry
- Drivers, Restraints and Opportunities
- Market Segmentation
- Global Oligonucleotide Synthesis Market, By Product, 2021 - 2031 (USD Million)
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Drugs
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Synthesized Oligo
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Reagents
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Equipment
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- Global Oligonucleotide Synthesis Market, By Type, 2021 - 2031 (USD Million)
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Custom
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Predesigned
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- Global Oligonucleotide Synthesis Market, By Application, 2021 - 2031 (USD Million)
- Therapeutic Applications
- Diagnostics
- Research
- Others
- Global Oligonucleotide Synthesis Market, By End User, 2021 - 2031 (USD Million)
- Academic Research Institutes
- Pharmaceutical and Biotechnology Companies
- Diagnostic Laboratories
- Others
- Global Oligonucleotide Synthesis Market, By Geography, 2021 - 2031 (USD Million)
- North America
- United States
- Canada
- Europe
- Germany
- United Kingdom
- France
- Italy
- Spain
- Nordic
- Benelux
- Rest of Europe
- Asia Pacific
- Japan
- China
- India
- Australia & New Zealand
- South Korea
- ASEAN (Association of South East Asian Countries)
- Rest of Asia Pacific
- Middle East & Africa
- GCC
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- North America
- Global Oligonucleotide Synthesis Market, By Product, 2021 - 2031 (USD Million)
- Competitive Landscape
- Company Profiles
- Danaher Corporation
- Thermo Fisher Scientific Inc
- Merck KGaA
- Eurofins Scientific
- LGC Limited
- Agilent Technologies Inc
- Kaneka Corporation
- Maravai Lifesciences Holdings Inc
- Azenta Inc
- Company Profiles
- Analyst Views
- Future Outlook of the Market