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By Product Type;
HPLC Columns, Normal Phase HPLC Columns, Reverse Phase HPLC Columns, Ion Exchange Columns, Size Exclusion Columns, RP/IEX Bimodal Mixed-Mode Columns, Silica-Based Multimodal Columns, and OthersBy Type;
Ion Exchange Chromatography and Affinity ChromatographyBy Capacity;
1-100 ML, 100-1000 ML, and More Than 1LBy Applications;
Monoclonal Antibodies, Non-Antibody Protein, Polyclonal Antibodies, and OthersBy Geography;
North America, Europe, Asia Pacific, Middle East & Africa, and Latin America - Report Timeline (2021 - 2031)Multimodal Chromatography Columns Market Overview
Multimodal Chromatography Columns Market (USD Million)
Multimodal Chromatography Columns Market was valued at USD 340.14 million in the year 2024. The size of this market is expected to increase to USD 546.19 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 7.0%.
Multimodal Chromatography Columns Market
*Market size in USD million
CAGR 7.0 %
| Study Period | 2025 - 2031 |
|---|---|
| Base Year | 2024 |
| CAGR (%) | 7.0 % |
| Market Size (2024) | USD 340.14 Million |
| Market Size (2031) | USD 546.19 Million |
| Market Concentration | Medium |
| Report Pages | 344 |
Major Players
- Bio-Rad Laboratories, Inc.
- DANAHER CORPORATION
- Agilent Technologies Inc.
- Merck KGAA
- Hitachi, Ltd.
- Restek Corporation
- PerkinElmer, Inc.
- Waters Corporation
- Shimadzu Corporation
Market Concentration
Consolidated - Market dominated by 1 - 5 major players
Multimodal Chromatography Columns Market
Fragmented - Highly competitive market without dominant players
The Multimodal Chromatography Columns Market is expanding rapidly due to rising needs for precision purification in biopharmaceutical processing, with adoption climbing by over 40%. These columns combine multiple interaction principles to improve separation efficiency, enhancing yields across protein, enzyme, and vaccine purification workflows. Companies are deploying targeted growth strategies to develop customizable formats for varied application needs. Ongoing collaboration with drug manufacturers is leading to improved process standardization and broader expansion of downstream purification systems.
Collaborative Product Development Boosting Functionality
Co-development initiatives have increased by more than 38%, with companies entering strategic collaborations to enhance performance across high-value biomolecule purification. These alliances are delivering new columns suited for monoclonal antibody, gene therapy, and enzyme purification, offering higher resolution and reusability. Several mergers within the bioseparation segment have resulted in broader product portfolios. These joint efforts are unlocking targeted solutions that deliver long-term growth and accommodate advanced regulatory and quality demands in bioprocessing.
Expanded Use Across Biopharma and CDMO Facilities
The use of multimodal columns has risen by over 42% in contract development and manufacturing organizations as well as large-scale pharmaceutical plants. Their adaptability across purification steps has made them a preferred choice for flexible processing lines. Manufacturers are refining growth strategies through modular formats, disposable units, and scalable production systems. Growing partnerships with biopharma firms are fueling product customization and operational integration, supporting wide-reaching expansion in both clinical and commercial-scale environments.
Future Outlook Focused on Process Intensification
More than 44% of developers are focusing on intelligent resin matrices and inline process monitoring as part of the market’s future outlook. With greater emphasis on yield, speed, and purity, new systems are being designed for single-use implementation and automation readiness. Continued innovation in ligand specificity and pressure-tolerant housings is expected to reshape column utility across downstream purification. These efforts are supported by aggressive expansion strategies that target intensified manufacturing and faster product turnaround in next-generation therapies.
Multimodal Chromatography Columns Market Recent Developments
- Product Launches: Leading players in the market have been launching new products to meet the growing demand for biopharmaceutical purification. These new products often incorporate the latest technological advancements to offer superior performance. For instance, several companies have introduced columns that combine different interaction modes, such as hydrophobic interaction and ion exchange, to provide greater flexibility and efficiency in purification processes.
- Strategic Collaborations and Partnerships: Collaboration between companies and research institutions has been on the rise. These partnerships aim to leverage combined expertise and resources to accelerate the development of innovative chromatography solutions. For example, collaborations between biopharmaceutical companies and chromatography technology providers are focusing on developing customized solutions for specific purification challenges in biologics production.
Multimodal Chromatography Columns Market Segment Analysis
In this report, the Multimodal Chromatography Columns Market has been segmented by Product Type, Type, Capacity, Applications and Geography.
Multimodal Chromatography Columns Market, Segmentation by Product Type
The Multimodal Chromatography Columns Market has been segmented by HPLC Columns, Normal Phase HPLC Columns, Reverse Phase HPLC Columns, Ion Exchange Columns, Size Exclusion Columns, RP/IEX Bimodal Mixed-Mode Columns, Silica-Based Multimodal Columns, and Others
HPLC Columns
High-Performance Liquid Chromatography (HPLC) columns are a foundational product type in multimodal chromatography, widely used for precise separation of complex mixtures. These columns account for a significant share of the market, approximately 30%, due to their high efficiency and versatility in various applications including pharmaceuticals and biotechnology.
Normal Phase HPLC Columns
Normal Phase HPLC Columns operate by separating compounds based on polarity differences, making them essential for isolating non-polar to moderately polar molecules. This segment represents around 15% of the market, favored for its effective resolution in natural product analysis and fine chemical separations.
Reverse Phase HPLC Columns
Reverse Phase HPLC Columns dominate the chromatography market with a usage share close to 35%, primarily due to their compatibility with a wide range of analytes and solvents. These columns facilitate separation based on hydrophobic interactions and are critical in pharmaceutical development and environmental testing.
Ion Exchange Columns
Ion Exchange Columns, which separate ions and polar molecules based on charge, hold roughly 10-12% of the market share. They are pivotal in protein purification, water treatment, and biochemical research, providing high selectivity and capacity for charged analytes.
Size Exclusion Columns
Size Exclusion Columns separate molecules based on size, making them indispensable in polymer analysis and biopharmaceuticals. This sub-segment accounts for about 8% of the market, valued for its ability to characterize molecular weight distribution without affecting molecular structure.
RP/IEX Bimodal Mixed-Mode Columns
RP/IEX bimodal mixed-mode columns combine reverse phase and ion exchange mechanisms, offering enhanced separation capabilities. Although a niche market segment with approximately 5% share, these columns provide unique advantages in complex sample matrices, improving resolution and selectivity.
Silica-Based Multimodal Columns
Silica-Based Multimodal Columns utilize silica as the base material, known for its chemical stability and customizable surface chemistry. This segment comprises around 10% of the market, widely used for robust analytical and preparative chromatography processes.
Others
The ‘Others’ category includes emerging and specialized multimodal columns tailored for unique applications. While currently smaller in market share (around 3%), this segment is growing due to continuous innovation and demand for customized solutions in niche industries.
Multimodal Chromatography Columns Market, Segmentation by Type
The Multimodal Chromatography Columns Market has been segmented by Type into Ion Exchange Chromatography, Affinity Chromatography.
Ion Exchange Chromatography
Ion Exchange Chromatography is a widely used technique in the multimodal chromatography columns market, accounting for about 60% of the segment. This method separates molecules based on their charge differences and is essential in protein purification, pharmaceutical production, and water treatment processes due to its high selectivity and efficiency.
Affinity Chromatography
Affinity Chromatography represents approximately 40% of the multimodal chromatography columns market by type. This specialized technique relies on specific binding interactions between the target molecule and the ligand, making it highly effective for purifying biomolecules such as antibodies, enzymes, and nucleic acids with excellent specificity.
Multimodal Chromatography Columns Market, Segmentation by Capacity
The Multimodal Chromatography Columns Market has been segmented by Capacity into 1-100 ML, 100-1000 ML, and More Than 1L.
1-100 ML
The 1-100 ML capacity segment captures a significant portion of the multimodal chromatography columns market, accounting for nearly 50%. These smaller capacity columns are widely used in research and analytical laboratories for method development and small-scale purification due to their precision and ease of handling.
100-1000 ML
Columns with a capacity ranging from 100-1000 ML represent around 35% of the market. This mid-range segment is favored in pilot-scale purification and process optimization, offering a balance between throughput and resolution for biopharmaceutical and industrial applications.
More Than 1L
The large-capacity segment, exceeding 1 liter, comprises about 15% of the market share. These columns are primarily used in large-scale production environments, such as commercial bioprocessing, where high-volume purification is essential for cost-effective and efficient manufacturing.
Multimodal Chromatography Columns Market, Segmentation by Geography
In this report, the Multimodal Chromatography Columns Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East and Africa and Latin America.
Regions and Countries Analyzed in this Report
Multimodal Chromatography Columns Market Share (%), by Geographical Region
North America
North America holds a dominant position in the multimodal chromatography columns market, capturing around 35% of the global share. The region’s leadership is driven by strong pharmaceutical and biotechnology industries, advanced healthcare infrastructure, and high adoption of innovative chromatography technologies.
Europe
Europe accounts for approximately 30% of the market, supported by extensive research activities, well-established biopharmaceutical sectors, and favorable regulatory frameworks. Countries such as Germany, the UK, and France are key contributors to this growth.
Asia Pacific
The Asia Pacific region is rapidly emerging, representing about 25% of the market. Growth here is fueled by increasing biopharmaceutical manufacturing, rising investments in healthcare infrastructure, and expanding research and development activities, especially in China, India, and Japan.
Middle East and Africa
Middle East and Africa currently contribute around 5% to the multimodal chromatography columns market. The market in this region is gradually expanding due to growing awareness, improving healthcare facilities, and rising demand for biopharmaceutical products.
Latin America
Latin America holds nearly 5% of the global market share. The region is witnessing steady growth due to increasing pharmaceutical manufacturing activities, government initiatives to boost healthcare, and rising adoption of advanced chromatographic techniques.
Market Trends
This report provides an in depth analysis of various factors that impact the dynamics of Global Multimodal Chromatography Columns Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.
Drivers, Restraints and Opportunity Analysis
Drivers:
- Expanding pharmaceutical industry
- New product launches
- Regulatory approval facilitation
- Increasing chronic diseases
-
Rising biologics development - The rising development of biologics is a critical driver for the global multimodal chromatography columns market. Biologics, which include a wide range of products such as monoclonal antibodies, vaccines, cell therapies, and gene therapies, have revolutionized the treatment landscape for various diseases, particularly chronic and complex conditions like cancer, rheumatoid arthritis, and multiple sclerosis. As the global burden of these diseases increases, so does the demand for biologics, driving the need for efficient and high-capacity purification methods.
Multimodal chromatography columns are uniquely suited to meet this demand due to their ability to utilize multiple interaction modes within a single column. This capability allows for the separation and purification of complex biomolecules with higher selectivity and efficiency compared to traditional single-mode chromatography techniques. The versatility of multimodal chromatography enables it to handle a diverse array of biologic products, which often vary significantly in their chemical and physical properties.
The biotechnology and pharmaceutical industries are heavily investing in the development of new biologics, with many companies expanding their biologics pipelines. This trend is supported by significant advancements in biotechnology, including recombinant DNA technology and hybridoma technology, which have facilitated the production of a wide range of biologic products. As these products move from research and development phases to clinical trials and ultimately to market approval, the demand for robust and scalable purification processes, such as those offered by multimodal chromatography columns, continues to grow.
Moreover, regulatory agencies are increasingly approving biologics for a variety of therapeutic indications, further fueling the market expansion. The growing acceptance and adoption of biologics in clinical practice underscore the need for reliable and efficient purification technologies. Multimodal chromatography columns, with their enhanced performance and adaptability, are well-positioned to support the burgeoning biologics market, ensuring the production of high-quality therapeutic products that meet stringent regulatory standards.
Restraints:
- Limited skilled professionals
- High operational costs
- Competition from alternatives
- Stringent quality standards
-
Limited awareness levels - Limited awareness levels pose a significant restraint to the growth of the global multimodal chromatography columns market. Despite the clear advantages offered by multimodal chromatography, such as enhanced selectivity and efficiency in the purification of complex biomolecules, its adoption is hindered by a lack of widespread knowledge and understanding among potential users, particularly in emerging markets and smaller research institutions.
Many researchers and laboratory technicians are more familiar with traditional chromatography techniques, such as ion exchange, size exclusion, and affinity chromatography. The transition to multimodal chromatography requires not only an understanding of its theoretical principles but also practical training and experience to optimize its application. This knowledge gap can lead to hesitation and resistance in adopting new technologies, slowing down the integration of multimodal chromatography into standard laboratory practices.
Furthermore, the limited availability of educational resources and training programs exacerbates this issue. Many institutions, especially those with constrained budgets, may not have access to comprehensive training modules or expert guidance on multimodal chromatography. This lack of resources can result in suboptimal use of the technology, reducing its perceived effectiveness and benefits.
Manufacturers of multimodal chromatography columns must invest in educational initiatives to bridge this awareness gap. This includes providing detailed technical documentation, conducting workshops, and offering hands-on training sessions. Collaborating with academic institutions and industry associations to integrate multimodal chromatography into educational curricula can also play a crucial role in raising awareness and competence among future scientists and technicians.
Opportunities:
- Increasing biosimilars development
- Contract research organizations
- Personalized medicine trend
- Expanding research activities
-
Government funding increase - The increase in government funding presents a significant opportunity for the growth of the global multimodal chromatography columns market. Government investments in healthcare, research, and development play a crucial role in advancing scientific discoveries and technological innovations. This funding is particularly impactful in the biotechnology and pharmaceutical sectors, where the development and production of biologics and other complex biomolecules require substantial financial resources.
One of the primary areas where government funding can make a difference is in supporting research initiatives aimed at improving and expanding the capabilities of multimodal chromatography. By providing grants and subsidies to academic institutions, research organizations, and private companies, governments can facilitate the development of more efficient and versatile chromatography columns. These advancements can lead to better purification processes, higher product yields, and lower production costs, ultimately benefiting the entire biopharmaceutical industry.
In addition to direct research funding, governments often invest in the development of infrastructure that supports scientific and medical research. This includes the establishment of state-of-the-art laboratories, research parks, and innovation hubs equipped with advanced technologies like multimodal chromatography columns. These facilities provide researchers with the tools and environment needed to conduct cutting-edge research and development, fostering innovation and accelerating the commercialization of new products.
Government funding also plays a pivotal role in education and training programs. By investing in the education of scientists, technicians, and healthcare professionals, governments can ensure a skilled workforce capable of utilizing advanced chromatography techniques. This not only enhances the quality of research but also promotes the adoption of multimodal chromatography in various applications, from basic research to industrial-scale production.
Competitive Landscape Analysis
Key players in Global Multimodal Chromatography Columns Market include:
- Bio-Rad Laboratories, Inc.
- DANAHER CORPORATION
- Agilent Technologies Inc.
- Merck KGAA
- Hitachi, Ltd.
- Restek Corporation
- PerkinElmer, Inc.
- Waters Corporation
- Shimadzu Corporation
In this report, the profile of each market player provides following information:
- Company Overview and Product Portfolio
- Key Developments
- Financial Overview
- Strategies
- Company SWOT Analysis
- Introduction
- Research Objectives and Assumptions
- Research Methodology
- Abbreviations
- Market Definition & Study Scope
- Executive Summary
- Market Snapshot, By Product Type
- Market Snapshot, By Type
- Market Snapshot, By Capacity
- Market Snapshot, By Applications
- Market Snapshot, By Region
- Multimodal Chromatography Columns Market Dynamics
- Drivers, Restraints and Opportunities
- Drivers
- Expanding pharmaceutical industry
- New product launches
- Regulatory approval facilitation
- Increasing chronic diseases
- Rising biologics development
- Restraints
- Limited skilled professionals
- High operational costs
- Competition from alternatives
- Stringent quality standards
- Limited awareness levels
- Opportunities
- Increasing biosimilars development
- Contract research organizations
- Personalized medicine trend
- Expanding research activities
- Government funding increase
- Drivers
- PEST Analysis
- Political Analysis
- Economic Analysis
- Social Analysis
- Technological Analysis
- Porter's Analysis
- Bargaining Power of Suppliers
- Bargaining Power of Buyers
- Threat of Substitutes
- Threat of New Entrants
- Competitive Rivalry
- Drivers, Restraints and Opportunities
- Market Segmentation
- Multimodal Chromatography Columns Market, By Product Type, 2021 - 2031 (USD Million)
- HPLC Columns
- Normal Phase HPLC Columns
- Reverse Phase HPLC Columns
- Ion Exchange Columns
- Size exclusion columns
- RP/IEX bimodal mixed-mode columns
- Silica-Based Multimodal Columns
- Others
- Multimodal Chromatography Columns Market, By Type, 2021 - 2031 (USD Million)
- Ion Exchange Chromatography
- Affinity Chromatography
- Multimodal Chromatography Columns Market, By Capacity, 2021 - 2031 (USD Million)
- 1-100 ML
- 100-1000 ML
- More Than 1L
- Multimodal Chromatography Columns Market, By Applications, 2021 - 2031 (USD Million)
- Monoclonal Antibodies
- Non-antibody protein
- Polyclonal Antibodies
- Other
- Multimodal Chromatography Columns Market, By Geography, 2021 - 2031 (USD Million)
- North America
- United States
- Canada
- Europe
- Germany
- United Kingdom
- France
- Italy
- Spain
- Nordic
- Benelux
- Rest of Europe
- Asia Pacific
- Japan
- China
- India
- Australia & New Zealand
- South Korea
- ASEAN (Association of South East Asian Countries)
- Rest of Asia Pacific
- Middle East & Africa
- GCC
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- North America
- Multimodal Chromatography Columns Market, By Product Type, 2021 - 2031 (USD Million)
- Competitive Landscape
- Company Profiles
- Bio-Rad Laboratories, Inc.
- DANAHER CORPORATION
- Agilent Technologies Inc.
- Merck KGAA
- Hitachi, Ltd.
- Restek Corporation
- PerkinElmer, Inc.
- Waters Corporation
- Shimadzu Corporation
- Company Profiles
- Analyst Views
- Future Outlook of the Market