Global Gene Synthesis Market Growth, Share, Size, Trends and Forecast (2025 - 2031)

The global gene synthesis market has experienced significant growth due to advances in synthetic biology, rising demand for personalized medicine, and expanding applications in biotechnology and pharmaceutical industries. Synthetic biology, which involves redesigning organisms for useful purposes by engineering them to have new abilities, has driven the demand for gene synthesis. Personalized medicine, which tailors treatment to individual patients based on their genetic profiles, requires precise and custom-designed genes, further propelling the market. Increased research and development activities in genomics and the development of novel therapeutics have contributed to the expansion of this market.

The market is segmented based on product type, application, end-user, and region. By product type, the market is divided into gene library synthesis, custom gene synthesis, and others. Custom gene synthesis dominates the market due to its extensive use in research and therapeutic development. Applications of gene synthesis include diagnostics, therapeutics, research, and industrial biotechnology. The therapeutic segment, in particular, is growing rapidly as gene therapies for various genetic disorders and cancers become more prevalent. Key end-users of gene synthesis products are academic and research institutions, pharmaceutical and biotechnology companies, and contract research organizations (CROs). Among these, pharmaceutical and biotechnology companies are the largest segment due to their role in drug discovery and development.

Regionally, North America holds the largest share of the global gene synthesis market, attributed to substantial investments in biotech research, the presence of leading gene synthesis companies, and strong governmental support for genomic research. Europe follows closely, driven by similar factors and robust healthcare infrastructure. The Asia-Pacific region is anticipated to witness the fastest growth during the forecast period, fueled by increasing R&D activities, rising healthcare expenditure, and growing awareness about synthetic biology. Countries like China and India are emerging as significant players in the market due to their expanding biotech industries and favorable regulatory environments. Overall, the global gene synthesis market is poised for continued growth, driven by technological advancements and increasing applications across various fields.

Global Gene Synthesis Market Segment Analysis

The Global Gene Synthesis Market Has Been Segmented By Method, Component, Gene Type, End User and Geography.

Global Gene Synthesis Market, Segmentation by Method

The Global Gene Synthesis Market Has Been Segmented By Method into Oligonucleotide Synthesis and Gene Assembly.

The global gene synthesis market, a crucial component of biotechnology and genetic engineering, is broadly segmented into two primary methods: oligonucleotide synthesis and gene assembly. Oligonucleotide synthesis involves the chemical synthesis of short DNA or RNA sequences, commonly known as oligos. These oligos are essential for a range of applications, including polymerase chain reactions (PCR), DNA sequencing, gene editing, and as probes in diagnostic tests. The demand for oligonucleotide synthesis has surged due to advancements in synthetic biology, personalized medicine, and the rising prevalence of genetic disorders. This method is highly automated and cost-effective, making it accessible for both research and clinical applications.

Gene assembly, on the other hand, involves the construction of longer DNA sequences from oligonucleotides. This method allows for the synthesis of entire genes and even whole genomes, enabling researchers to create novel genetic sequences that do not exist in nature. Gene assembly techniques, such as Gibson assembly, Golden Gate assembly, and CRISPR-Cas9 mediated assembly, have revolutionized genetic engineering by providing tools for precise gene editing and synthetic biology applications. These techniques are pivotal in the development of genetically modified organisms (GMOs), gene therapies, and synthetic vaccines. The growing interest in synthetic biology, agricultural biotechnology, and therapeutic interventions has significantly boosted the gene assembly market.

Both oligonucleotide synthesis and gene assembly are critical to the ongoing expansion of the gene synthesis market. Innovations in automation, accuracy, and cost reduction have propelled the accessibility and utility of these methods. The integration of these techniques in pharmaceutical development, diagnostics, and biotechnological research underscores their importance. As the field of synthetic biology continues to evolve, the demand for advanced gene synthesis technologies is expected to rise, driving further growth in the market. The synergy between oligonucleotide synthesis and gene assembly not only enhances our understanding of genetic functions but also paves the way for groundbreaking developments in medicine, agriculture, and environmental science.

Global Gene Synthesis Market, Segmentation by Component

The Global Gene Synthesis Market Has Been Segmented By Component into Synthesizer, Consumables, Software and Services.

The Global Gene Synthesis Market is segmented into four primary components: synthesizers, consumables, software, and services. Synthesizers are specialized machines used to create synthetic DNA sequences, a foundational aspect of gene synthesis. These devices have seen significant advancements, making the synthesis process faster, more accurate, and cost-effective. Major players in the market continually innovate to improve the throughput and efficiency of synthesizers, catering to the growing demand from various sectors such as pharmaceuticals, biotechnology, and academic research.

Consumables in the gene synthesis market include reagents, enzymes, oligonucleotides, and other materials required for the synthesis process. These consumables are essential for the operational efficiency of synthesizers and are recurrently purchased, providing a steady revenue stream for companies. The demand for high-quality consumables is driven by the need for precise and reliable synthesis processes, as inaccuracies can lead to significant setbacks in research and development. Companies are focusing on providing a broad range of consumables that are compatible with different synthesizers and applications, enhancing their market presence.

Software and services are also critical components of the gene synthesis market. Software solutions are employed to design synthetic genes, optimize synthesis protocols, and manage data, which enhances the overall efficiency and accuracy of gene synthesis. Services, on the other hand, encompass custom synthesis, consultation, and support services provided by specialized firms. These services are crucial for researchers and companies that may lack the in-house capabilities or expertise to carry out complex synthesis tasks. The growth of the gene synthesis market is further propelled by the increasing demand for personalized medicine, synthetic biology applications, and advancements in genomic research, all of which require sophisticated software and high-quality services to meet specific project needs.

Global Gene Synthesis Market, Segmentation by Gene Type

The Global Gene Synthesis Market Has Been Segmented By Gene Type into Standard Gene, Express Gene, Complex Gene and Others.

The global gene synthesis market is a rapidly expanding sector within biotechnology, driven by advancements in genetic research and the increasing demand for customized DNA sequences. One key segment within this market is the standard gene synthesis. Standard genes are typically less complex and are widely used in basic research, academic studies, and routine laboratory applications. These genes are synthesized to facilitate the study of gene function, protein expression, and the creation of various genetic models. The simplicity and widespread applicability of standard genes make them a significant portion of the market, catering to a broad range of scientific inquiries and educational purposes.

Another critical segment is express gene synthesis, which involves the creation of genes designed to be highly expressed in specific host organisms. This segment is particularly relevant for industrial applications, including the production of pharmaceuticals, enzymes, and biofuels. Express genes are engineered to maximize protein yield and are often used in the development of therapeutic proteins and other biologically active compounds. The demand for express genes is driven by the biotechnology and pharmaceutical industries, which require reliable and efficient gene synthesis methods to support large-scale production and commercialization of bioproducts.

The complex gene synthesis segment addresses the need for synthesizing large, intricate DNA sequences that include multiple elements such as regulatory regions, introns, and exons. These genes are essential for advanced genetic engineering projects, synthetic biology, and the development of genetically modified organisms (GMOs). Complex gene synthesis is also crucial for creating multi-gene constructs and pathways used in metabolic engineering and synthetic biology applications. As research moves towards more sophisticated genetic modifications and synthetic life forms, the demand for complex gene synthesis continues to grow. Other segments within the market include custom genes, oligonucleotides, and gene fragments, each catering to specific research needs and applications, further diversifying the market landscape.

Global Gene Synthesis Market, Segmentation by End User

The Global Gene Synthesis Market Has Been Segmented By End User into Academic & Research Institute, Biopharmaceutical Companies and Contract Research Organizations.

The global gene synthesis market is segmented by end users, including academic and research institutes, biopharmaceutical companies, and contract research organizations (CROs). Academic and research institutes are significant players in the gene synthesis market, leveraging synthesized genes for basic research, functional genomics studies, and the development of innovative therapies. These institutions are often at the forefront of scientific discovery, utilizing gene synthesis technologies to understand gene functions, create genetic models, and develop new biological tools. The growing focus on personalized medicine and genomics research in these institutes propels the demand for advanced gene synthesis services.

Biopharmaceutical companies are another crucial segment in the global gene synthesis market. These companies utilize gene synthesis to develop new drugs, vaccines, and therapeutic proteins. The ability to design and synthesize genes with high precision allows biopharmaceutical companies to create targeted treatments for various diseases, including cancer, genetic disorders, and infectious diseases. The increasing prevalence of chronic diseases and the ongoing advancements in biotechnology fuel the demand for gene synthesis in this sector. Biopharmaceutical companies are heavily investing in synthetic biology to engineer microorganisms for the production of complex pharmaceuticals, further driving market growth.

Contract research organizations (CROs) play a pivotal role in the gene synthesis market by providing outsourced research services to academic institutions and biopharmaceutical companies. CROs offer specialized expertise and capabilities in gene synthesis, enabling their clients to accelerate research and development processes while reducing costs. These organizations support various stages of drug discovery and development, from initial gene synthesis to preclinical studies and clinical trials. The growing trend of outsourcing in the pharmaceutical and biotechnology industries, driven by the need for cost-efficiency and access to specialized knowledge, is a significant factor contributing to the expansion of the gene synthesis market within the CRO segment.

Global Gene Synthesis Market, Segmentation by Geography

The Global Gene Synthesis Market Has Been Segmented By Geography into five regions; North America, Europe, Asia Pacific, Middle East, Africa and Latin America.

Global Gene Synthesis Market Share (%), by Geographical Region, 2024

North America, led by the United States, dominates the market due to its well-established biotechnology sector, substantial funding for genetic research, and a robust infrastructure supporting genomics. The presence of key market players, extensive academic research institutions, and high adoption of advanced technologies further bolster the market in this region. Canada's growing investment in life sciences and biotechnology also contributes to the market's strength in North America.

Europe holds a significant share in the gene synthesis market, driven by countries like Germany, the United Kingdom, and France. These nations boast strong research communities, government support for scientific endeavors, and active participation in international collaborations. The European Union's funding programs and regulatory frameworks support genetic research and innovation, enhancing the market's growth. The region's focus on personalized medicine, gene therapy, and synthetic biology further stimulates demand for gene synthesis services and products.

The Asia Pacific region is emerging as a major player in the gene synthesis market, with China, Japan, and South Korea at the forefront. Rapid advancements in biotechnology, substantial government investments, and the proliferation of research institutions and biotech companies fuel market growth. China's ambitious initiatives in genomics, Japan's technological innovations, and South Korea's robust R&D infrastructure contribute to the region's dynamic market expansion. Meanwhile, the Middle East and Africa, although currently smaller markets, are showing potential with increasing healthcare investments and research activities. Latin America, led by Brazil and Mexico, is gradually growing due to rising awareness of biotechnological applications and improving research infrastructure, despite facing economic and regulatory challenges.

This report provides an in depth analysis of various factors that impact the dynamics of Global Gene Synthesis Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.

Drivers, Restraints and Opportunity Analysis

Drivers:

• Use in drug discovery and development
• Expansion of synthetic biology research programs
• Innovations in genomics and proteomics research

• Growth in academic and industrial research project: The global gene synthesis market has witnessed substantial growth in academic and industrial research projects due to advancements in biotechnology and genetic engineering. In academia, gene synthesis is pivotal for various research applications, including gene function studies, synthetic biology, and the development of genetically modified organisms (GMOs). Researchers benefit from the ability to custom-design genes, which accelerates the pace of genetic research and allows for precise manipulation of genetic sequences. This has led to significant breakthroughs in understanding genetic diseases, developing new therapies, and exploring the potentials of synthetic biology. The availability of high-fidelity gene synthesis services and the reduction in synthesis costs have further fueled the expansion of gene synthesis applications in academic settings.

  In the industrial sector, gene synthesis has become an essential tool for biopharmaceutical development, agricultural biotechnology, and bioengineering. Companies are leveraging gene synthesis to develop novel therapeutics, such as gene therapies, vaccines, and biologics, which require the precise and efficient creation of specific genetic sequences. In agriculture, gene synthesis is used to engineer crops with enhanced traits such as pest resistance, improved yield, and stress tolerance. Industrial biotechnology applications include the production of biofuels, biodegradable plastics, and other bioproducts through engineered microorganisms. The integration of automated and high-throughput gene synthesis technologies in industrial research has significantly improved the efficiency and scalability of these processes, thereby driving the market's growth.

Restraints:

• Regulatory Challenges
• Complexity of Data Interpretation
• Ethical Concerns and Public Perception

• High Costs of Technology and Implementation: The high costs associated with technology and implementation in the global gene synthesis market stem from several key factors. First, the development and maintenance of cutting-edge equipment required for gene synthesis are expensive. Advanced technologies such as high-throughput DNA synthesizers and next-generation sequencing platforms demand substantial investment in both initial acquisition and ongoing maintenance. The precision and reliability necessary in gene synthesis processes necessitate continual updates and upgrades to the technology, further driving up costs. These sophisticated tools are crucial for ensuring accuracy and efficiency in gene synthesis but come at a significant financial burden.

  The implementation phase adds to the overall expense due to the need for skilled personnel and robust infrastructure. Employing highly trained scientists and technicians who can operate these complex machines and interpret the results is essential, and their expertise commands high salaries. Setting up a laboratory equipped to handle gene synthesis involves considerable expenditure on infrastructure, including specialized facilities to maintain the required sterile and controlled environments. Regulatory compliance and quality control measures also contribute to the costs, as they necessitate rigorous testing, validation, and certification processes to meet industry standards and ensure the safety and efficacy of synthesized genes. Together, these factors create a high barrier to entry and operational cost, impacting the overall market dynamics and accessibility.

Opportunities:

• Innovations in CRISPR and gene-editing technologies
• Custom gene synthesis for individualized treatment plans
• Growth in personalized and precision medicine applications

• Expansion in gene therapy and personalized drug development: The global gene synthesis market is witnessing significant growth, driven in part by advancements in gene therapy and personalized drug development. Gene therapy, which involves the direct modification or manipulation of genes to treat or prevent disease, has gained momentum with the approval of several high-profile therapies. These therapies are tailored to address genetic disorders at their root cause, offering potential cures rather than just symptomatic relief. The success of treatments like CAR-T cell therapy for certain cancers and Luxturna for retinal dystrophy has spurred investment and innovation in this field. As gene therapy techniques become more refined and widespread, the demand for custom gene synthesis services to create the necessary genetic constructs and vectors is expanding rapidly. This is further accelerated by regulatory bodies becoming more receptive to these novel treatments, streamlining approval processes and fostering an environment conducive to growth.

  Parallel to the advancements in gene therapy, personalized drug development is transforming the pharmaceutical landscape. Personalized medicine tailors treatments based on individual genetic profiles, ensuring higher efficacy and reduced side effects. The integration of genomics into drug development allows for the identification of specific genetic mutations and variations that can be targeted with custom-designed therapies. This approach not only improves patient outcomes but also optimizes the drug development pipeline by focusing on targeted populations likely to benefit the most. The increasing adoption of next-generation sequencing (NGS) and other genomic technologies has bolstered the capacity to synthesize genes quickly and accurately, catering to the specific needs of personalized treatment regimens. As a result, the gene synthesis market is poised for robust growth, supported by the ongoing advancements in gene therapy and personalized medicine, which collectively aim to revolutionize how diseases are treated and managed on a global scale.

Key players in Global Gene Synthesis Market include:

• ATDBio Ltd (U.K.)
• General Biosystems, Inc. (U.S.)
• Boster Biological Technology (U.S.)
• Creative Biogene (U.S.)
• Bioneer Pacific (South Korea)
• exonbio (U.S.)
• trenzyme GmbH (Germany)
• Twist Bioscience (U.S.)
• BioCat GmbH (Germany)
• OriGene Technologies, Inc. (U.S.)
• Integrated DNA Technologies, Inc. (U.S.)
• Eurofins Scientific (Luxembourg)
• Nzy Tech (Portugal)

In this report, the profile of each market player provides following information:

• Company Overview and Product Portfolio
• Key Developments
• Financial Overview
• Strategies
• Company SWOT Analysis