Critical Limb Ischemia Treatment Market

By Treatment;

Devices, Drugs- [Antihypertensive Agents, Antiplatelet Drugs, Antithrombotic Agents, Lipid-Lowering Agents, and Others] and Surgery

By Devices;

Embolic Protection Devices and Peripheral Dilatation System- [Balloon Dilators and Vascular Stents]

By Route of administration;

Oral and Parentral

By End-use;

Hospitals and Ambulatory Surgical Centers

By Geography;

North America, Europe, Asia Pacific, Middle East & Africa, and Latin America - Report Timeline (2021 - 2031)
Report ID: Rn732333012 Published Date: August, 2025 Updated Date: September, 2025

Critical Limb Ischemia Treatment Market Overview

Critical Limb Ischemia Treatment Market (USD Million)

Critical Limb Ischemia Treatment Market was valued at USD 4,093.02 million in the year 2024. The size of this market is expected to increase to USD 6,969.37 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 7.9%.


Critical Limb Ischemia Treatment Market

*Market size in USD million

CAGR 7.9 %


Study Period2025 - 2031
Base Year2024
CAGR (%)7.9 %
Market Size (2024)USD 4,093.02 Million
Market Size (2031)USD 6,969.37 Million
Market ConcentrationMedium
Report Pages397
4,093.02
2024
6,969.37
2031

Major Players

  • Abbott Laboratories
  • Cesca Therapeutics Inc.
  • LimFlow SA
  • Boston Scientific Corporation
  • Micro Medical Solutions
  • Pluristem Therapeutics Inc
  • Rexgenero Ltd.

Market Concentration

Consolidated - Market dominated by 1 - 5 major players

Critical Limb Ischemia Treatment Market

Fragmented - Highly competitive market without dominant players


The Critical Limb Ischemia Treatment Market is gaining momentum as rising cases of severe peripheral artery disease create urgent demand for advanced therapeutic solutions. Nearly 12% of people worldwide experience peripheral vascular issues, and around 20% of them progress to critical limb ischemia, reinforcing the need for effective interventions. With a growing focus on lowering amputation rates and enhancing survival outcomes, the market is witnessing strong advancements in both surgical and non-surgical treatment approaches.

Rising Need for Effective Interventions
The increasing prevalence of diabetes and cardiovascular conditions significantly contributes to treatment demand. More than 40% of diabetic patients are vulnerable to vascular complications, with nearly 30% of ischemia cases requiring prompt surgical or endovascular care. This underscores the growing requirement for advanced therapies that not only save limbs but also improve long-term health outcomes.

Innovations in Treatment Options
Emerging technologies such as minimally invasive endovascular procedures, angioplasty, and stenting are transforming the therapeutic approach. Studies reveal that 45% of patients achieve positive results with less invasive methods, leading to shorter recovery periods and reduced healthcare expenditures. In addition, progress in regenerative medicine, including stem-cell therapies, is opening new doors for improved clinical effectiveness.

Growth Factors Driving Market
With a 50% rise in clinical research targeting innovative biologics and cell-based therapies, the market is poised for expansion. Enhanced healthcare investments and supportive reimbursement structures are broadening patient access to modern treatments. As clinical outcomes continue to validate new therapeutic models, the Critical Limb Ischemia Treatment Market is establishing itself as a critical domain in managing high-risk vascular disorders.

  1. Introduction
    1. Research Objectives and Assumptions
    2. Research Methodology
    3. Abbreviations
  2. Market Definition & Study Scope
  3. Executive Summary
    1. Market Snapshot, By Treatment
    2. Market Snapshot, By Devices
    3. Market Snapshot, By Route of administration
    4. Market Snapshot, By End-use
    5. Market Snapshot, By Region
  4. Critical Limb Ischemia Treatment Market Dynamics
    1. Drivers, Restraints and Opportunities
      1. Drivers:
        1. Increasing Prevalence of Peripheral Artery Disease (PAD)
        2. Advancements in Minimally Invasive Procedures
        3. Rising Geriatric Population
        4. Growing Awareness and Early Diagnosis of Critical Limb Ischemia
      2. Restraints:
        1. High Treatment Costs
        2. Limited Healthcare Access in Low-Income Regions
        3. Stringent Regulatory Approvals for Medical Devices and Drugs
      3. Opportunities:
        1. Rising Investment in Healthcare Infrastructure in Emerging Markets
        2. Technological Innovations in Medical Devices and Surgical Techniques
        3. Expanding Focus on Personalized and Targeted Treatments
    2. PEST Analysis
      1. Political Analysis
      2. Economic Analysis
      3. Social Analysis
      4. Technological Analysis
    3. Porter's Analysis
      1. Bargaining Power of Suppliers
      2. Bargaining Power of Buyers
      3. Threat of Substitutes
      4. Threat of New Entrants
      5. Competitive Rivalry
  5. Market Segmentation
    1. Critical Limb Ischemia Treatment Market, By Treatment, 2021 - 2031 (USD Million)
      1. Devices
      2. Drugs
        1. Antihypertensive Agents
        2. Antiplatelet Drugs
        3. Antithrombotic Agents
        4. Lipid-lowering Agents
        5. Others
      3. Surgery
    2. Critical Limb Ischemia Treatment Market, By Devices, 2021 - 2031 (USD Million)
      1. Embolic Protection Devices
      2. Peripheral Dilatation System
        1. Balloon Dilators
        2. Vascular Stents
    3. Critical Limb Ischemia Treatment Market, By Route of administration, 2021 - 2031 (USD Million)

      1. Oral

      2. Parentral

    4. Critical Limb Ischemia Treatment Market, By End-use, 2021 - 2031 (USD Million)

      1. Hospitals

      2. Ambulatory Surgical Centers

    5. Critical Limb Ischemia Treatment Market, By Geography, 2021 - 2031 (USD Million)
      1. North America
        1. United States
        2. Canada
      2. Europe
        1. Germany
        2. United Kingdom
        3. France
        4. Italy
        5. Spain
        6. Nordic
        7. Benelux
        8. Rest of Europe
      3. Asia Pacific
        1. Japan
        2. China
        3. India
        4. Australia & New Zealand
        5. South Korea
        6. ASEAN (Association of South East Asian Countries)
        7. Rest of Asia Pacific
      4. Middle East & Africa
        1. GCC
        2. Israel
        3. South Africa
        4. Rest of Middle East & Africa
      5. Latin America
        1. Brazil
        2. Mexico
        3. Argentina
        4. Rest of Latin America
  6. Competitive Landscape
    1. Company Profiles
      1. Abbott Laboratories
      2. Cesca Therapeutics Inc.
      3. LimFlow SA
      4. Boston Scientific Corporation
      5. Micro Medical Solutions
      6. Pluristem Therapeutics Inc
      7. Rexgenero Ltd.
  7. Analyst Views
  8. Future Outlook of the Market