Complex Regional Pain Syndrome Market

By Disease Type;

CRPS I, CRPS II, and CRPS-NOS

By Treatment;

Medication (Analgesics, Antidepressants, Corticosteroids, Opioids, and Other Medications) and Therapy (Physical Therapy, Intrathecal Drug Pump, Spinal Cord Stimulation, Surgical Sympathectomy, and Other Therapies)

By Route of Administration;

Oral and Intravenous

By Distribution Channel;

Hospital Pharmacy, Drug Stores, Retail Pharmacy, and E-commerce

By Geography;

North America, Europe, Asia Pacific, Middle East & Africa, and Latin America - Report Timeline (2021 - 2031)
Report ID: Rn447706645 Published Date: August, 2025 Updated Date: September, 2025

Complex Regional Pain Syndrome Market Overview

Complex Regional Pain Syndrome Market (USD Million)

Complex Regional Pain Syndrome Market was valued at USD 112.00 million in the year 2024.The size of this market is expected to increase to USD 131.41 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 2.3%.


Complex Regional Pain Syndrome Market

*Market size in USD million

CAGR 2.3 %


Study Period2025 - 2031
Base Year2024
CAGR (%)2.3 %
Market Size (2024)USD 112.00 Million
Market Size (2031)USD 131.41 Million
Market ConcentrationHigh
Report Pages322
112.00
2024
131.41
2031

Major Players

  • Boston Scientific Corporation
  • Medtronic
  • GlaxoSmithKline plc
  • Johnson & Johnson
  • Mylan N.V
  • Abiogen Pharma SpA
  • Axsome Therapeutics
  • Grunenthal GmbH
  • Mallinckrodt Plc

Market Concentration

Consolidated - Market dominated by 1 - 5 major players

Complex Regional Pain Syndrome Market

Fragmented - Highly competitive market without dominant players


The Complex Regional Pain Syndrome (CRPS) Market is witnessing significant growth due to increasing awareness and advancements in pain management therapies. Rising cases of neuropathic pain disorders and improved diagnosis rates have contributed to higher treatment adoption, with nearly 40% of patients opting for advanced therapeutic solutions.

Growing Adoption of Innovative Treatments
Innovations in neurostimulation devices, regenerative therapies, and minimally invasive interventions are shaping the CRPS market landscape. Approximately 35% of healthcare providers are now integrating spinal cord stimulation and nerve block techniques into patient care, improving treatment success rates and reducing dependency on conventional pain medications.

Increasing Focus on Research & Development
Continuous investment in R&D is driving the development of novel drug candidates and biologic therapies aimed at managing CRPS more effectively. Around 42% of pharmaceutical companies are prioritizing clinical trials for neuropathic pain management, accelerating the introduction of advanced formulations and personalized treatment approaches.

Rising Role of Multidisciplinary Care
The adoption of multidisciplinary treatment models has increased considerably, combining pharmacological therapy, physical rehabilitation, and psychological support. Studies indicate that 45% of CRPS patients show significant improvement with integrated care strategies, underscoring the importance of comprehensive treatment frameworks in enhancing patient recovery outcomes.

  1. Introduction
    1. Research Objectives and Assumptions
    2. Research Methodology
    3. Abbreviations
  2. Market Definition & Study Scope
  3. Executive Summary
    1. Market Snapshot, By Disease Type
    2. Market Snapshot, By Treatment
    3. Market Snapshot, By Route of Administration
    4. Market Snapshot, By Distribution Channel
    5. Market Snapshot, By Region
  4. Complex Regional Pain Syndrome Market Dynamics
    1. Drivers, Restraints and Opportunities
      1. Drivers
        1. Advancements in Treatment Options
        2. Growing Geriatric Population
        3. Increasing Healthcare Expenditure
        4. Technological Innovations
        5. Focus on Multimodal Pain Management
      2. Restraints
        1. Limited Understanding and Diagnosis
        2. Lack of Standardized Treatment Guidelines
        3. High Cost of Treatment
        4. Limited Efficacy of Current Therapies
      3. Opportunities
        1. Increasing Awareness and Diagnosis
        2. Advancements in Treatment Modalities
        3. Rising Healthcare Expenditure
        4. Focus on Personalized Medicine
        5. Patient-Centric Care Models
    2. PEST Analysis
      1. Political Analysis
      2. Economic Analysis
      3. Social Analysis
      4. Technological Analysis
    3. Porter's Analysis
      1. Bargaining Power of Suppliers
      2. Bargaining Power of Buyers
      3. Threat of Substitutes
      4. Threat of New Entrants
      5. Competitive Rivalry

  5. Market Segmentation
    1. Complex Regional Pain Syndrome Market, By Disease Type, 2021 - 2031 (USD Million)

      1. CRPS I

      2. CRPS II

      3. CRPS-NOS

    2. Complex Regional Pain Syndrome Market, By Treatment, 2021 - 2031 (USD Million)
      1. Medication

        1. Analgesics

        2. Antidepressants

        3. Corticosteroids

        4. Opioids

        5. Other medications

      2. Therapy

        1. Physical therapy

        2. Intrathecal drug pump

        3. Spinal cord stimulation

        4. Surgical sympathectomy

        5. Other therapies

    3. Complex Regional Pain Syndrome Market, By Route of Administration, 2021 - 2031 (USD Million)
      1. Oral
      2. Intravenous
    4. Complex Regional Pain Syndrome Market, By Distribution Channel, 2021 - 2031 (USD Million)
      1. Hospital Pharmacy
      2. Drug Stores
      3. Retail Pharmacy
      4. E-commerce
    5. Complex Regional Pain Syndrome Market, By Geography, 2021 - 2031 (USD Million)
      1. North America
        1. United States
        2. Canada
      2. Europe
        1. Germany
        2. United Kingdom
        3. France
        4. Nordic
        5. Benelux
        6. Italy
        7. Spain
        8. Rest of Europe
      3. Asia Pacific
        1. Japan
        2. China
        3. India
        4. Australia & New Zealand
        5. South Korea
        6. ASEAN (Association of South East Asian Countries)
        7. Rest of Asia Pacific
      4. Middle East & Africa
        1. GCC
        2. Israel
        3. South Africa
        4. Rest of Middle East & Africa
      5. Latin America
        1. Brazil
        2. Mexico
        3. Argentina
        4. Rest of Latin America
  6. Competitive Landscape
    1. Company Profiles
      1. Boston Scientific Corporation
      2. Medtronic
      3. GlaxoSmithKline plc
      4. Johnson & Johnson
      5. Mylan N.V
      6. Abiogen Pharma SpA
      7. Axsome Therapeutics
      8. Grunenthal GmbH
      9. Mallinckrodt Plc
  7. Analyst Views
  8. Future Outlook of the Market