Chemotherapy Induced Nausea and Vomiting (CINV) Drugs Market
By Type;
Acute Emesis, Delayed Emesis, Anticipatory Emesis and Refractory EmesisBy Therapy;
Nk-1 Receptor Antagonist, Serotonin Receptor Antagonist and OthersBy Drug Type;
Branded and GenericsBy Route of Administration;
Oral and ParenteralBy End User;
Hospitals, Specialty Clinics, Home Healthcare and OthersBy Geography;
North America, Europe, Asia Pacific, Middle East & Africa and Latin America - Report Timeline (2021 - 2031)Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market Overview
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market (USD Million)
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market was valued at USD 1,733.34 million in the year 2024. The size of this market is expected to increase to USD 1,972.01 million by the year 2031, while growing at a Compounded Annual Growth Rate (CAGR) of 1.9%.
Chemotherapy Induced Nausea and Vomiting (CINV) Drugs Market
*Market size in USD million
CAGR 1.9 %
Study Period | 2025 - 2031 |
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Base Year | 2024 |
CAGR (%) | 1.9 % |
Market Size (2024) | USD 1,733.34 Million |
Market Size (2031) | USD 1,972.01 Million |
Market Concentration | High |
Report Pages | 359 |
Major Players
- Eisai
- ProStrakan
- Helsinn Holding
- Mundipharma
- Qilu Pharma
- Novartis AG
- Heron Therapeutics
- Roche
- Tesaro
- Helsinn Holding S.A.
- Baxter
- Orchid Healthcare
- Sun Pharmaceutical Industries Ltd.
Market Concentration
Consolidated - Market dominated by 1 - 5 major players
Chemotherapy Induced Nausea and Vomiting (CINV) Drugs Market
Fragmented - Highly competitive market without dominant players
The Chemotherapy Induced Nausea and Vomiting (CINV) Drugs Market is becoming increasingly vital as cancer treatment expands worldwide. Nearly 70% of patients undergoing chemotherapy face nausea and vomiting, making effective management essential for maintaining quality of life and ensuring treatment adherence.
Key Drivers Shaping Market Growth
One of the strongest growth drivers is the rising focus on patient-centric care, with around 55% of oncologists prioritizing supportive drugs to minimize side effects. This shift has led to broader adoption of modern CINV therapies and an increasing reliance on multi-drug regimens.
Innovations Enhancing Treatment Outcomes
Recent innovations in drug design have reshaped treatment strategies, with about 60% of new drugs aiming to provide longer-lasting relief and minimize recurrence. Breakthroughs in 5-HT3 receptor antagonists and NK1 inhibitors are setting new benchmarks in symptom control.
Role of Strategies and Collaborations
Strategic partnerships and collaborations have also strengthened the market landscape. Over 40% of leading pharmaceutical firms are actively pursuing co-development projects, which has accelerated clinical testing and improved accessibility to advanced drugs worldwide.
Future Outlook for the Market
Looking ahead, the future of this market is highly promising. More than 65% of ongoing research explores novel combinations and improved delivery systems, paving the way for enhanced effectiveness. With rising awareness of supportive care in oncology, the market is well positioned for continued expansion.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market Recent Developments
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In June 2023, the FDA approved a new formulation of the neurokinin-1 (NK1) receptor antagonist, aprepitant, specifically designed to enhance patient adherence and reduce nausea and vomiting symptoms. Aprepitant works by blocking substance P, which binds to NK1 receptors in the central nervous system, a pathway heavily involved in emetic responses during chemotherapy.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market Segment Analysis
In this report, the Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Type, Therapy, Drug Type, Route of Administration, End User and Geography.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By Type
The Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Type into Acute Emesis, Delayed Emesis, Anticipatory Emesis and Refractory Emesis.
Acute Emesis
Acute emesis dominates the CINV drugs market, accounting for nearly 40–42% of the share. It occurs within 24 hours of chemotherapy, with prevalence rates of ≈70–80% among patients receiving highly emetogenic regimens. Advanced antiemetic drugs have reduced incidence levels by 50–60%, making this the largest and most actively managed segment.
Delayed Emesis
Delayed emesis contributes around 30–32% of the market and typically appears 24–120 hours after chemotherapy. Affecting nearly 60–65% of patients, it remains a major challenge due to its longer-lasting impact on quality of life. Combination therapies with NK-1 receptor antagonists and corticosteroids have improved control rates to nearly 70%.
Anticipatory Emesis
Anticipatory emesis holds about 15–17% of the market, triggered by psychological conditioning before chemotherapy sessions. It affects around 20–25% of patients, particularly those with prior severe emetic episodes. Interventions such as behavioral therapy and adjunctive pharmacologic strategies have reduced recurrence rates by 30–35%.
Refractory Emesis
Refractory emesis accounts for 10–12% of the CINV drugs market and occurs when symptoms persist despite optimal prophylaxis and treatment. It affects about 15–20% of high-risk patients, posing significant management difficulties. Newer multi-agent regimens have shown improvement rates of 25–30%, though unmet needs remain high in this segment.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By Therapy
The Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Therapy into Nk-1 Receptor Antagonist, Serotonin Receptor Antagonist and Others.
NK-1 Receptor Antagonist
NK-1 receptor antagonists dominate the CINV drugs market with nearly 40–45% share. These therapies effectively block substance P-mediated pathways, significantly reducing both acute and delayed emesis. Clinical studies show success rates of 70–75%, making them the preferred option in combination regimens for highly emetogenic chemotherapy.
Serotonin Receptor Antagonist
Serotonin receptor antagonists account for about 35–37% of the market, widely used as first-line prophylaxis for acute nausea and vomiting. Drugs in this class achieve response rates of nearly 65–70%, especially when combined with corticosteroids. Their affordable cost and widespread availability support high adoption in both developed and emerging markets.
Others
The others category holds around 18–20% share, including dopamine antagonists, corticosteroids, and benzodiazepines used as adjunct therapies. While their standalone efficacy averages 50–55%, they are highly effective when integrated into multi-drug regimens. Increasing use in personalized treatment approaches is expected to support steady growth in this segment.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By Drug Type
The Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Drug Type into Branded and Generics.
Branded
Branded drugs dominate the CINV drugs market with a share of nearly 55–58%, driven by their proven clinical efficacy and physician preference. These drugs often show success rates above 70% in controlling both acute and delayed emesis. However, their higher cost limits accessibility in low- and middle-income regions, where generics are increasingly preferred.
Generics
Generics account for about 42–45% of the market, offering cost-effective alternatives with therapeutic efficacy comparable to branded drugs. Adoption has been rising steadily, particularly in emerging economies, where generics contribute to treatment penetration rates of nearly 65–70%. Their affordability and wider availability are fueling strong market expansion.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By Route of Administration
The Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Route of Administration into Oral and Parenteral.
Oral
Oral administration dominates the CINV drugs market with nearly 60–62% share, owing to its ease of use and high patient compliance rates of 80–85%. Oral formulations provide convenience for both acute and delayed emesis management, making them the preferred choice in outpatient and homecare settings. Their widespread adoption is also supported by cost-effectiveness and accessibility.
Parenteral
Parenteral administration accounts for about 38–40% of the market, commonly used in hospital and specialty care settings for rapid symptom control. With efficacy rates above 75%, parenteral delivery is preferred in severe cases or when oral administration is not feasible. However, the need for clinical supervision and higher costs restrict its broader use compared to oral formulations.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By End User
The Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by End User into Hospitals, Specialty Clinics, Home Healthcare and Others.
Hospitals
Hospitals dominate the CINV drugs market with a share of nearly 45–48%, as they provide comprehensive cancer care along with immediate access to supportive therapies. With treatment adherence levels above 85%, hospitals remain the primary setting for both parenteral and oral drug administration. Their strong infrastructure ensures efficient management of acute and refractory emesis cases.
Specialty Clinics
Specialty clinics account for about 25–28% of the market, focusing on oncology-specific treatments and personalized care. These clinics report patient satisfaction levels of nearly 80% due to tailored treatment plans and continuous monitoring. Their growing presence, especially in urban regions, is strengthening their role in outpatient chemotherapy care.
Home Healthcare
Home healthcare contributes around 15–18% of the market, driven by the rising demand for cost-effective and convenient treatment options. Oral CINV drugs dominate this setting, with compliance rates of nearly 75–80%. Remote monitoring tools and supportive services are expanding the adoption of home-based care, especially among elderly patients.
Others
The others segment, comprising retail pharmacies and community healthcare providers, holds about 8–10% of the market. These facilities improve drug accessibility in semi-urban and rural regions, ensuring treatment availability beyond major hospital networks. With increasing awareness programs, this segment is witnessing annual growth of nearly 10–12%.
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, Segmentation By Geography
In this report, the Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East & Africa and Latin America.
Regions and Countries Analyzed in this Report
Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market Share (%), By Geographical Region
North America
North America leads the CINV drugs market with a share of nearly 38–40%, supported by advanced oncology care infrastructure, high chemotherapy adoption rates, and strong presence of leading pharmaceutical players. The U.S. drives the majority of this share with treatment adherence rates above 85% and significant investments in drug innovation.
Europe
Europe contributes about 27–30% of the global market, driven by government-supported cancer treatment programs and widespread use of generic CINV drugs. Countries such as Germany, France, and the UK record success rates of nearly 75% with combination therapies. Strong reimbursement policies further boost adoption across the region.
Asia Pacific
Asia Pacific accounts for around 22–24% of the market, propelled by a rising cancer burden and expanding healthcare infrastructure in China, India, and Japan. Increased availability of low-cost generics and improved diagnostic coverage have enhanced treatment penetration by 15–20% in recent years. Growing awareness is further accelerating adoption in this region.
Middle East & Africa
Middle East & Africa represent nearly 6–8% of the CINV drugs market, limited by restricted access to advanced treatment. However, rising government initiatives and international healthcare collaborations are improving drug availability. Awareness campaigns are gradually raising diagnosis and treatment rates to nearly 65% in urban areas.
Latin America
Latin America contributes about 7–9% of the global market, led by Brazil and Mexico. Expanding private healthcare services and government-backed cancer treatment programs are driving demand. With treatment adoption rising by 12–15% in recent years, the region is emerging as a key growth hub for affordable CINV drug solutions.
Market Trends
This report provides an in depth analysis of various factors that impact the dynamics of Global Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.
Drivers, Restraints and Opportunity Analysis
Drivers:- Advancements in Treatment Modalities
- Increasing Incidence of Cancer
- Growing Demand for Targeted Therapies
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Increasing Cancer Incidence - Rising Cancer Prevalence: The increasing global incidence of cancer is a significant driver for the demand for chemotherapy-induced nausea and vomiting (CINV) drugs. With cancer being one of the leading causes of mortality worldwide, the growing number of cancer cases necessitates the use of chemotherapy, which often leads to CINV. As cancer diagnoses rise across various demographics and regions, the demand for effective CINV drugs is expected to escalate.
Expanding Treatment Options: Advances in cancer treatment, including the development of new chemotherapeutic agents and the expansion of oncology research, contribute to the need for effective CINV drugs. With the introduction of novel cancer therapies, there is a parallel need for supportive care medications to manage the adverse effects, including nausea and vomiting. The availability of a broader range of treatment options for different types and stages of cancer leads to increased utilization of chemotherapy, consequently driving the demand for CINV drugs.
Restraints:
- Adverse Effects and Safety Concerns
- Limited Efficacy in Some Patient Populations
- High Cost of Branded Medications
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Regulatory Hurdles and Compliance Challenges - Regulatory hurdles and compliance challenges pose significant restraints to the development and commercialization of chemotherapy-induced nausea and vomiting (CINV) drugs. The pharmaceutical industry is subject to stringent regulatory requirements enforced by regulatory bodies such as the Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) in Europe. Obtaining regulatory approval for new CINV drugs involves extensive preclinical and clinical testing to demonstrate safety, efficacy, and quality, which can be time-consuming and expensive.
Navigating the complex regulatory landscape requires substantial financial resources and expertise in regulatory affairs. Companies must adhere to strict guidelines and standards throughout the drug development process, from preclinical research to clinical trials and post-marketing surveillance. Any failure to comply with regulatory requirements can result in delays in approval or even rejection of drug applications, leading to significant setbacks in product development timelines and financial losses.
Evolving regulatory frameworks and changing guidelines further complicate the regulatory landscape for CINV drugs. Regulatory agencies continuously update their requirements and expectations, necessitating ongoing monitoring and adaptation by pharmaceutical companies. Keeping pace with these changes requires significant investments in regulatory intelligence and compliance infrastructure, adding to the overall cost and complexity of bringing new CINV drugs to market. As a result, regulatory hurdles and compliance challenges represent formidable barriers to entry for drug developers in the CINV therapeutics space.
Opportunities:
- Advancements in Drug Delivery Systems
- Expansion of Target Patient Populations
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Development of Targeted Therapies - Advancements in understanding the molecular pathways underlying chemotherapy-induced nausea and vomiting (CINV) have opened up opportunities for the development of targeted therapies. By targeting specific receptors or pathways involved in the emetic response, pharmaceutical companies can design drugs with higher efficacy and fewer side effects. These targeted therapies may offer significant advantages over traditional antiemetic agents, providing better control of symptoms and improving the quality of life for patients undergoing chemotherapy.
The identification of new molecular targets associated with CINV, such as neurokinin-1 (NK-1) receptors and serotonin receptors, has spurred research into novel drug candidates. Pharmaceutical companies are investing in the development of selective NK-1 receptor antagonists and other targeted agents to address the unmet needs in CINV management. By leveraging advancements in drug discovery technologies and computational biology, researchers aim to create more potent and selective drugs that can effectively prevent or alleviate chemotherapy-induced nausea and vomiting, presenting promising opportunities for the future of CINV therapy.
Competitive Landscape Analysis
Key players in Global Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market include:
- Eisai
- ProStrakan
- Helsinn Holding
- Mundipharma
- Qilu Pharma
- Novartis AG
- Heron Therapeutics
- Roche
- Tesaro
- Helsinn Holding S.A.
- Baxter
- Orchid Healthcare
- Sun Pharmaceutical Industries Ltd.
In this report, the profile of each market player provides following information:
- Company Overview and Product Portfolio
- Key Developments
- Financial Overview
- Strategies
- Company SWOT Analysis
- Introduction
- Research Objectives and Assumptions
- Research Methodology
- Abbreviations
- Market Definition & Study Scope
- Executive Summary
- Market Snapshot, By Type
- Market Snapshot, By Therapy
- Market Snapshot, By Drug Type
- Market Snapshot, By Route of Administration
- Market Snapshot, By End User
- Market Snapshot, By Region
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market Dynamics
- Drivers, Restraints and Opportunities
- Drivers
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Advancements in Treatment Modalities
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Increasing Incidence of Cancer
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Growing Demand for Targeted Therapies
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Increasing Cancer Incidence
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- Restraints
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Adverse Effects and Safety Concerns
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Limited Efficacy in Some Patient Populations
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High Cost of Branded Medications
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Regulatory Hurdles and Compliance Challenges
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- Opportunities
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Advancements in Drug Delivery Systems
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Expansion of Target Patient Populations
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Development of Targeted Therapies
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- Drivers
- PEST Analysis
- Political Analysis
- Economic Analysis
- Social Analysis
- Technological Analysis
- Porter's Analysis
- Bargaining Power of Suppliers
- Bargaining Power of Buyers
- Threat of Substitutes
- Threat of New Entrants
- Competitive Rivalry
- Drivers, Restraints and Opportunities
- Market Segmentation
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Type, 2021 - 2031 (USD Million)
- Acute Emesis
- Delayed Emesis
- Anticipatory Emesis
- Refractory Emesis
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Therapy, 2021 - 2031(USD Million)
- Nk-1 Receptor Antagonist
- Serotonin Receptor Antagonist
- Others
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Drug Type, 2021- 2031 (USD Million)
- Branded
- Generics
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Route of Administration, 2021 - 2031 (USD Million)
- Oral
- Parenteral
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By End User, 2021 - 2031 (USD Million)
- Hospitals
- Specialty Clinics
- Home Healthcare
- Others
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Geography, 2021 - 2031 (USD Million)
- North America
- United States
- Canada
- Europe
- Germany
- United Kingdom
- France
- Italy
- Spain
- Nordic
- Benelux
- Rest of Europe
- Asia Pacific
- Japan
- China
- India
- Australia & New Zealand
- South Korea
- ASEAN (Association of South East Asian Countries)
- Rest of Asia Pacific
- Middle East & Africa
- GCC
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- North America
- Chemotheraphy Induced Nausea And Vomitting (CINV) Drugs Market, By Type, 2021 - 2031 (USD Million)
- Competitive Landscape
- Company Profiles
- Eisai
- ProStrakan
- Helsinn Holding
- Mundipharma
- Qilu Pharma
- Novartis AG
- Heron Therapeutics
- Roche
- Tesaro
- Helsinn Holding S.A.
- Baxter
- Orchid Healthcare
- Sun Pharmaceutical Industries Ltd.
- Company Profiles
- Analyst Views
- Future Outlook of the Market