Amyloidosis Treatment Market

• Market Growth The global amyloidosis treatment market is projected to reach USD 11.13 billion by 2033, growing at a CAGR of 7.5% from 2025 to 2033.

• Regional Dynamics North America held the largest market share of 39.36% in 2024, driven by advanced healthcare infrastructure and increased awareness. The Asia Pacific region is expected to register the fastest growth during the forecast period.

• Dominant Treatment Modalities Chemotherapy was the leading treatment approach, accounting for 26.5% of the market share in 2024. Targeted therapies are gaining traction due to their efficacy in managing specific amyloidosis types.

• End-User Distribution Hospitals and clinics were the primary end-users, comprising 49.4% of the market share in 2024, owing to their capacity to provide specialized care and advanced diagnostic services.

• Emerging Therapies Novel treatments, such as eplontersen (Wainua) and patisiran (Onpattro), are transforming the landscape of amyloidosis care by targeting the underlying genetic causes of the disease.

• Diagnostic Advancements Innovations in genetic testing and biomarker-based diagnostics are enabling earlier and more accurate detection of amyloidosis, facilitating timely intervention and improved patient outcomes.

• Market Challenges High treatment costs and limited access to specialized care in certain regions pose significant challenges to the widespread adoption of advanced amyloidosis therapies.

In this report, the Amyloidosis Treatment Market has been segmented by Type, Treatment, Route of Administration, End-use, and Geography.

Amyloidosis Treatment Market, Segmentation by Type

The Amyloidosis Treatment Market has been segmented by Type into AL Amyloidosis, AA Amyloidosis, Hereditary ATTR Amyloidosis, Wild-type ATTR Amyloidosis, and Others.

AL Amyloidosis
AL Amyloidosis is the most prevalent form, accounting for nearly 50% of all amyloidosis cases. It results from the abnormal production of light chains by plasma cells and primarily affects the heart and kidneys. Increased awareness and improved diagnostics are driving demand for targeted treatment regimens in this segment.

AA Amyloidosis
AA Amyloidosis represents around 10–15% of the market and is typically linked with chronic inflammatory conditions. It predominantly impacts the liver, spleen, and kidneys. The segment sees rising treatment adoption due to a growing incidence of chronic infections and autoimmune disorders.

Hereditary ATTR Amyloidosis
Hereditary ATTR Amyloidosis accounts for roughly 5–10% of the market, driven by genetic mutations leading to misfolded transthyretin proteins. Recent FDA approvals of gene-silencing therapies and transthyretin stabilizers are significantly boosting therapeutic uptake in this segment.

Wild-type ATTR Amyloidosis
This type is increasingly identified in aging populations, comprising nearly 20% of all ATTR cases. Unlike hereditary ATTR, wild-type ATTR is not inherited and mainly affects older males. Advances in imaging and non-invasive diagnostics are propelling growth in this segment.

Others
The “Others” category includes rare forms like dialysis-related amyloidosis and localized amyloidosis. Although they collectively account for under 5% of the market, these forms are gaining attention due to improvements in biomarker research and evolving clinical trials.

Amyloidosis Treatment Market, Segmentation by Treatment

The Amyloidosis Treatment Market has been segmented by Treatment into Chemotherapy, Supportive Care, Surgery, Stem Cell Transplant and Targeted Therapy.

Chemotherapy
Chemotherapy remains a frontline treatment, especially for AL amyloidosis, and constitutes approximately 40% of total treatments. It aims to suppress abnormal plasma cell production using agents like melphalan and cyclophosphamide. Combination regimens are being widely adopted to enhance patient outcomes and survival rates.

Supportive Care
Supportive care accounts for about 20% of the treatment landscape, primarily focusing on managing symptoms and improving quality of life. It includes interventions like diuretics, pain management, and nutritional support. This segment is crucial in advanced-stage amyloidosis or ineligible patients for aggressive therapies.

Surgery
Surgical intervention represents nearly 10% of the market and is often used for organ-specific complications such as carpal tunnel syndrome or intestinal obstructions. Although less common, surgery plays a vital role in palliative care and in enhancing functionality in localized amyloidosis.

Stem Cell Transplant
Stem cell transplant, particularly autologous stem cell transplantation (ASCT), accounts for about 15% of the treatment share. It is predominantly used in younger AL amyloidosis patients with good organ function. Despite its effectiveness, patient eligibility and post-transplant risks limit its widespread use.

Targeted Therapy
Targeted therapy is rapidly growing, comprising around 15% of the treatment market. It includes monoclonal antibodies, RNA interference drugs, and transthyretin stabilizers. These therapies offer precision treatment options with fewer systemic side effects and have gained traction due to recent FDA approvals.

Amyloidosis Treatment Market, Segmentation by Route of Administration

The Amyloidosis Treatment Market has been segmented by Route of Administration into Oral and Injectable

Oral
The oral route dominates the market with a share of approximately 55%, due to ease of administration and improved patient compliance. Treatments such as transthyretin stabilizers and small molecule therapies are commonly delivered orally. The rise in home-based care and chronic disease management further fuels the preference for oral formulations.

Injectable
Injectable therapies account for around 45% of the market and include monoclonal antibodies, RNA interference drugs, and chemotherapy agents. Despite requiring clinical administration, injectables are preferred for rapid action and bioavailability, especially in hospital settings and advanced amyloidosis cases.

Amyloidosis Treatment Market, Segmentation by End-use

The Amyloidosis Treatment Market has been segmented by End-use into Hospitals & Clinics, Ambulatory Surgical Centers, Home Care Settings, and Others.

Hospitals & Clinics
Hospitals & Clinics lead the market with over 50% share, driven by access to specialized diagnostic tools, experienced personnel, and advanced therapeutic interventions. These settings handle the majority of complex amyloidosis cases, particularly those requiring multidisciplinary care and continuous monitoring.

Ambulatory Surgical Centers
Ambulatory Surgical Centers (ASCs) contribute to nearly 20% of the market. Their cost-effectiveness, shorter wait times, and streamlined procedures make them suitable for specific outpatient interventions and diagnostic procedures in amyloidosis management.

Home Care Settings
Home Care Settings are gaining traction, representing around 15% of the market. With rising demand for chronic disease management and oral therapies, patients prefer the convenience and comfort of in-home care, especially in early-stage or non-aggressive amyloidosis cases.

Others
The "Others" segment, including research institutions and long-term care centers, holds approximately 15% share. These settings are crucial for clinical trials, palliative care, and supporting patients with rare or late-stage conditions that require specialized care beyond standard treatment centers.

Amyloidosis Treatment Market, Segmentation by Geography

In this report, the Amyloidosis Treatment Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East, and Africa, and Latin America.

North America
North America dominates the market with over 40% share, supported by high awareness, robust healthcare infrastructure, and strong research and development investments. The region benefits from rapid regulatory approvals and the presence of leading pharmaceutical companies offering innovative therapies.

Europe
Europe accounts for approximately 25% of the global market. Favorable reimbursement policies, growing geriatric population, and increased adoption of targeted treatments are key growth drivers. Countries like Germany and the UK are at the forefront of therapeutic advancements and clinical trials.

Asia Pacific
Asia Pacific is emerging as the fastest-growing region, holding nearly 20% share. Rising healthcare expenditure, expanding diagnostic access, and increasing awareness of rare diseases like amyloidosis are boosting market demand, particularly in India, China, and Japan.

Middle East and Africa
The Middle East and Africa contribute around 8% to the market, with growth primarily driven by increasing government efforts to improve healthcare accessibility. However, limited diagnostic infrastructure and affordability challenges still constrain broader market penetration.

Latin America
Latin America holds an estimated 7% share, led by markets such as Brazil and Mexico. Improvements in healthcare delivery, combined with rising focus on early diagnosis and treatment of rare diseases, are enhancing regional uptake of amyloidosis therapies.

This report provides an in depth analysis of various factors that impact the dynamics of Global Amyloidosis Treatment Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.

Drivers, Restraints and Opportunities Analysis

Drivers:

• Increasing disease prevalence worldwide
• Advancements in diagnostic techniques
• Growing awareness initiatives globally
• Rising healthcare expenditure internationally

• Improved therapeutic options available: The global amyloidosis treatment market has witnessed significant advancements in recent years, driven by the development of improved therapeutic options. Traditional treatment methods, such as chemotherapy and autologous stem cell transplants, have been complemented by novel targeted therapies that offer better outcomes with fewer side effects. These new therapies include monoclonal antibodies like daratumumab, which specifically target amyloid fibrils, and RNA interference (RNAi) drugs such as patisiran and inotersen, which inhibit the production of amyloidogenic proteins. The approval of these targeted treatments has not only expanded the therapeutic arsenal against amyloidosis but also provided patients with more personalized and effective treatment regimens.

  The market growth is bolstered by ongoing research and clinical trials aimed at identifying and developing new therapeutic agents. Pharmaceutical companies are investing heavily in the discovery of small molecules, gene therapies, and other innovative approaches to address the underlying mechanisms of amyloidosis. Additionally, increased awareness and early diagnosis of the disease have contributed to the rising demand for these advanced treatments. As a result, the amyloidosis treatment market is expected to grow robustly, providing hope for improved patient outcomes and a better quality of life for those affected by this complex and often debilitating condition.

Restraints:

• High treatment costs
• Limited treatment accessibility
• Stringent regulatory approvals
• Side effects of drugs

• Lack of skilled professionals: The global amyloidosis treatment market is facing a significant challenge due to the lack of skilled professionals. Amyloidosis, a rare and complex disease characterized by the abnormal deposition of amyloid proteins in tissues and organs, requires highly specialized knowledge for effective diagnosis and treatment. The scarcity of healthcare professionals with expertise in this area leads to delays in diagnosis, misdiagnosis, and suboptimal treatment outcomes. This shortage is particularly acute in developing regions, where medical infrastructure and training programs may be less advanced. Consequently, patients in these areas often have limited access to advanced diagnostic tools and specialized care, exacerbating the overall burden of the disease.

  The intricate nature of amyloidosis demands continuous education and training for healthcare providers to stay updated with the latest advancements in diagnostic techniques and therapeutic options. The rapid pace of medical research and the introduction of novel treatment modalities, such as targeted therapies and gene-editing technologies, further underscore the need for a well-trained workforce. Addressing this gap requires concerted efforts from medical institutions, industry stakeholders, and government bodies to enhance educational programs, provide incentives for specialization in rare diseases, and facilitate international collaborations. Such measures are crucial to improving patient outcomes and ensuring that advancements in amyloidosis treatment can be effectively translated into clinical practice globally.

Opportunities:

• Emerging market expansion
• Technological advancements in treatment
• Collaborative research initiatives
• Personalized medicine development

• Government funding support: The global amyloidosis treatment market has been experiencing significant growth, driven by advancements in medical research and increasing awareness of the disease. Amyloidosis, characterized by the abnormal accumulation of amyloid proteins in organs and tissues, requires complex and often costly treatment regimens. Government funding plays a crucial role in supporting research and development (R&D) efforts aimed at discovering new therapies and improving existing ones. This financial backing is essential for conducting clinical trials, which are critical for the approval of new treatments by regulatory bodies. Governments across various countries, including the United States, European Union nations, and Japan, have been actively investing in amyloidosis research initiatives, providing grants and subsidies to academic institutions, biotechnology companies, and pharmaceutical firms. Such funding not only accelerates the pace of innovation but also ensures that new treatments are accessible to patients sooner.

  In addition to supporting R&D, government funding also facilitates public health initiatives aimed at early diagnosis and patient education. By investing in awareness campaigns and screening programs, governments can help identify amyloidosis cases at an earlier stage, allowing for timely intervention and better management of the disease. For instance, the National Institutes of Health (NIH) in the United States has been instrumental in promoting research on rare diseases, including amyloidosis, through various funding mechanisms. Similarly, the European Union's Horizon Europe program provides substantial grants for collaborative research projects focused on rare diseases. These efforts are crucial in addressing the unmet medical needs of amyloidosis patients, ultimately improving their quality of life and reducing the long-term burden on healthcare systems. As a result, government funding support is a key driver in the growth and development of the global amyloidosis treatment market.

Amyloidosis Treatment Market is characterized by intense competition, with around 58% of the share dominated by established pharmaceutical leaders. Companies are focusing on strategies involving advanced drug development, collaboration with research institutes, and targeted partnerships. The push for clinical innovation is shaping the market landscape and driving long-term growth prospects.

Market Structure and Concentration
Nearly 55% of the sector is consolidated among leading players, while emerging firms contribute niche innovations. Increasing mergers and acquisitions are strengthening market concentration. Strategic expansion by major companies enables them to capture wider patient segments, ensuring sustained growth across advanced treatment options and therapy portfolios.

Brand and Channel Strategies
Around 53% of companies enhance their brand visibility through effective distribution alliances and specialty channels. Multi-tier strategies include direct hospital engagement, strong partnerships with healthcare providers, and digital platforms. Enhanced marketing efforts and physician outreach are reinforcing growth and supporting better adoption of innovative treatment solutions.

Innovation Drivers and Technological Advancements
Close to 62% of firms prioritize technological advancements in precision medicine and targeted therapies. Significant innovation is achieved through collaboration with biotechnology companies and academia. Continuous investment in R&D pipelines ensures sustainable growth by delivering safer, more effective solutions and maintaining competitiveness in the evolving therapeutic environment.

Regional Momentum and Expansion
North America contributes nearly 40%, Europe close to 30%, and Asia-Pacific around 24% of the total share. Regional expansion is fueled by rising healthcare infrastructure and clinical trials. Tailored strategies and local partnerships allow companies to strengthen presence, ensuring balanced growth across both developed and emerging healthcare markets.

Future Outlook
More than 67% of companies are aligning strategies toward advanced biologics and innovative therapies. The future outlook emphasizes stronger collaboration, sustainable R&D models, and regional expansion. Long-term growth will be driven by breakthroughs in treatment delivery and increasing regulatory support for novel pharmaceutical innovations.

Key players in Amyloidosis Treatment Market include:

• Johnson & Johnson
• Pfizer Inc.
• GSK plc
• Takeda Pharmaceutical Company Limited
• Amgen Inc.
• Bristol-Myers Squibb Company
• Novartis AG
• F. Hoffmann-La Roche Ltd
• Merck KGaA
• Sanofi
• Alnylam Pharmaceuticals, Inc.
• Ionis Pharmaceuticals, Inc.
• BridgeBio Pharma Inc.
• Prothena Corporation plc
• AstraZeneca PLC

In this report, the profile of each market player provides following information:

• Market Share Analysis
• Company Overview and Product Portfolio
• Key Developments
• Financial Overview
• Strategies
• Company SWOT Analysis