Global Oligonucleotide Synthesis Market Growth, Share, Size, Trends and Forecast (2024 - 2030)
By Product;
Drugs, Synthesized Oligo, Reagents and Equipment.By Type;
Custom and Predesigned.By Geography;
North America, Europe, Asia Pacific, Middle East and Africa and Latin America - Report Timeline (2020 - 2030).Introduction
Global Oligonucleotide Synthesis Market (USD Million), 2020 - 2030
In the year 2023, the Global Oligonucleotide Synthesis Market was valued at USD 4,554.40 million. The size of this market is expected to increase to USD 10,290.64 million by the year 2030, while growing at a Compounded Annual Growth Rate (CAGR) of 12.4%.
Oligonucleotides, short sequences of nucleotides, are pivotal in genetic testing, molecular diagnostics, and drug development. The surge in demand for personalized medicine, alongside advances in biotechnology and genomics, has significantly bolstered the market. With the increasing prevalence of genetic disorders and chronic diseases, there is a heightened need for precise and reliable diagnostic tools, further propelling the market forward. The advent of innovative technologies such as CRISPR-Cas9 and next-generation sequencing has revolutionized genetic research, leading to a higher demand for custom oligonucleotides.
Pharmaceutical and biotechnological companies are heavily investing in oligonucleotide-based therapies, including antisense oligonucleotides, small interfering RNAs (siRNAs), and aptamers, to address a wide range of medical conditions, from rare genetic diseases to cancer. Additionally, the rise of synthetic biology and the growing interest in synthetic genes and genome editing are contributing to the market's expansion. The continuous advancements in oligonucleotide synthesis technologies have resulted in higher purity, better accuracy, and faster synthesis processes, making these vital molecules more accessible and cost-effective.
Global Oligonucleotide Synthesis Market Report Snapshot
Parameters | Description |
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Market | Global Oligonucleotide Synthesis Market |
Study Period | 2020 - 2030 |
Base Year (for Global Oligonucleotide Synthesis Market Size Estimates) | 2023 |
Drivers |
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Restriants |
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Opportunities |
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Segment Analysis
The segmentation by product encompasses a range of offerings tailored to different research and therapeutic needs. This includes synthesized oligonucleotides, which are custom-made sequences designed for specific applications such as PCR amplification, DNA sequencing, and gene synthesis. Additionally, oligonucleotide-based products such as primers, probes, and siRNAs are integral components in various molecular biology techniques and gene expression studies.
The market segmentation by type delineates different categories of oligonucleotides based on their structure, function, and application. This includes DNA oligonucleotides, which are short sequences of DNA molecules synthesized for use in genetic testing, cloning, and sequencing applications. RNA oligonucleotides, on the other hand, play crucial roles in gene expression regulation, RNA interference, and antisense therapy. Furthermore, modified oligonucleotides, including phosphorothioate, locked nucleic acid (LNA), and 2'-O-methylated oligonucleotides, offer enhanced stability, specificity, and pharmacokinetic properties for therapeutic applications.
Lastly, geographical segmentation provides insights into regional dynamics and market trends across different parts of the world. The global oligonucleotide synthesis market exhibits significant diversity in terms of regional demand, regulatory frameworks, and healthcare infrastructure. North America, comprising the United States and Canada, dominates the market owing to the presence of key industry players, robust research infrastructure, and high adoption rates of advanced biotechnologies. Europe follows closely, driven by increasing investments in genomic research and precision medicine initiatives. Asia-Pacific represents a rapidly growing market fueled by rising healthcare expenditure, expanding biopharmaceutical industry, and increasing focus on personalized medicine in countries such as China, Japan, and India.
Global Oligonucleotide Synthesis Segment Analysis
In this report, the Global Oligonucleotide Synthesis Market has been segmented by Product, Type and Geography.
Global Oligonucleotide Synthesis Market, Segmentation by Product
The Global Oligonucleotide Synthesis Market has been segmented by Product into Drugs, Synthesized Oligo, Reagents and Equipment.
Drugs constitute a significant segment within the market, encompassing oligonucleotide-based therapeutics designed to target specific genes or gene products implicated in various diseases. These drugs include antisense oligonucleotides, small interfering RNAs (siRNAs), and aptamers, among others, which hold promise for treating a wide range of medical conditions, including genetic disorders, viral infections, and cancer.
Synthesized oligonucleotides represent another key product category, comprising custom-made sequences synthesized to precise specifications for specific applications in molecular biology, genetic testing, and diagnostics. These synthesized oligonucleotides serve as essential tools in techniques such as polymerase chain reaction (PCR), DNA sequencing, and gene editing, facilitating research and development across academic, industrial, and clinical settings. Reagents constitute an indispensable component of oligonucleotide synthesis workflows, encompassing a variety of chemicals, enzymes, and buffers required for oligonucleotide synthesis, purification, and modification.
Global Oligonucleotide Synthesis Market, Segmentation by Type
The Global Oligonucleotide Synthesis Market has been segmented by Type into Custom and Predesigned.
Custom oligonucleotides represent a versatile and highly customizable category of products, synthesized to precise specifications based on the unique needs of individual researchers, laboratories, or projects. These custom oligonucleotides offer flexibility in sequence design, length, modifications, and purification methods, allowing researchers to tailor them for specific applications such as PCR primer design, gene synthesis, or targeted sequencing. Custom oligonucleotides are particularly valuable in research settings where precise control over sequence composition and functionality is essential for experimental success.
Predesigned oligonucleotides constitute a preselected catalog of sequences designed for common applications or research targets. These predesigned oligonucleotides offer convenience and time savings by providing readily available solutions for standard molecular biology techniques, gene expression assays, or diagnostic tests. Predesigned oligonucleotides are often optimized for performance and compatibility with popular experimental protocols, making them suitable for routine laboratory workflows and high-throughput applications.
Global Oligonucleotide Synthesis Market, Segmentation by Geography
In this report, the Global Oligonucleotide Synthesis Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East and Africa and Latin America.
Global Oligonucleotide Synthesis Market Share (%), by Geographical Region, 2023
North America emerges as a dominant market for oligonucleotide synthesis, primarily led by the United States. The region boasts a robust biotechnology sector, advanced research infrastructure, and a favorable regulatory environment, fostering innovation and driving market growth. The presence of key industry players, academic institutions, and research organizations further accelerates the adoption of oligonucleotide-based technologies in various applications, including drug discovery, diagnostics, and personalized medicine.
Europe constitutes another significant market for oligonucleotide synthesis, characterized by increasing investments in genomic research, biopharmaceutical development, and precision medicine initiatives. Countries such as the United Kingdom, Germany, and Switzerland are at the forefront of technological innovation, driving demand for custom oligonucleotides and advanced synthesis platforms.
Asia Pacific emerges as a rapidly growing market fueled by expanding biopharmaceutical industry, rising healthcare expenditure, and growing emphasis on personalized medicine across countries like China, Japan, and India. The region presents lucrative opportunities for market players, supported by government initiatives, research collaborations, and increasing adoption of oligonucleotide-based therapies in the region's burgeoning healthcare landscape.
Market Trends
This report provides an in depth analysis of various factors that impact the dynamics of Global Oligonucleotide Synthesis Market. These factors include; Market Drivers, Restraints and Opportunities.
Drivers:
- Advancements in Biotechnology and Genomics
- Growing Demand for Personalized Medicine
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Increasing Prevalence of Genetic Disorders and Chronic Diseases - Genetic disorders, encompassing a broad spectrum of inherited conditions resulting from abnormalities in an individual's genome, pose a substantial healthcare burden worldwide. These disorders can manifest across various organ systems and encompass diverse pathologies, ranging from rare genetic syndromes to more prevalent conditions such as cystic fibrosis, muscular dystrophy, and Huntington's disease.
Chronic diseases, including cardiovascular diseases, diabetes, cancer, and neurological disorders, represent a global epidemic, contributing to a significant proportion of morbidity and mortality worldwide. Many chronic diseases have underlying genetic components or are influenced by genetic predispositions, environmental factors, and lifestyle choices. As such, there is a growing recognition of the importance of understanding the genetic basis of these diseases for early diagnosis, risk assessment, and personalized treatment strategies.
Oligonucleotide synthesis plays a pivotal role in addressing the diagnostic and therapeutic challenges posed by genetic disorders and chronic diseases. Custom-designed oligonucleotides serve as indispensable tools for genetic testing, enabling the detection of disease-causing mutations, polymorphisms, and gene expression patterns. Furthermore, oligonucleotide-based technologies, such as antisense oligonucleotides, RNA interference (RNAi), and gene editing tools like CRISPR-Cas9, offer promising avenues for therapeutic intervention.
Restraints:
- High Cost of Oligonucleotide Synthesis
- Stringent Regulatory Requirements
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Limited Adoption in Developing Regions - One of the primary barriers to adoption is the lack of access to advanced biotechnology infrastructure and expertise in many developing countries. Oligonucleotide synthesis requires specialized equipment, reagents, and skilled personnel, which may be scarce or unavailable in resource-constrained settings. Additionally, limited investment in research and development infrastructure hampers the capacity of academic institutions, research organizations, and biotechnology companies in these regions to innovate and adopt cutting-edge oligonucleotide technologies.
Regulatory complexities and stringent quality control requirements present formidable hurdles for market entry and product commercialization in developing regions. Oligonucleotide-based products are subject to rigorous regulatory scrutiny and approval processes, which vary across countries and regions. Navigating these regulatory landscapes demands significant time, resources, and expertise, posing challenges for manufacturers and distributors seeking to penetrate emerging markets.
Opportunities:
- Rising Investment in Oligonucleotide-Based Therapies
- Technological Innovations in Synthesis Processes
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Expansion of Synthetic Biology and Genome Editing Applications - One of the key opportunities lies in the development of novel therapeutic modalities enabled by oligonucleotide-based genome editing technologies such as CRISPR-Cas9. These technologies offer unprecedented precision and efficiency in modifying DNA sequences, holding immense promise for treating genetic diseases, cancer, and infectious diseases. Oligonucleotides play pivotal roles as guide RNAs, donor templates, and delivery vehicles in CRISPR-mediated genome editing approaches, facilitating targeted genetic modifications with high specificity and minimal off-target effects.
The expansion of synthetic biology applications beyond traditional biomedicine presents new avenues for oligonucleotide synthesis. In industrial biotechnology, synthetic biology techniques are utilized to engineer microorganisms for the production of biofuels, chemicals, and pharmaceuticals. Oligonucleotides play critical roles in gene synthesis, pathway engineering, and gene regulation, enabling the design and optimization of microbial strains with enhanced metabolic capabilities and productivity.
Another emerging opportunity lies in the convergence of synthetic biology with fields such as agriculture, environmental biotechnology, and bioinformatics. Oligonucleotide-based technologies are instrumental in engineering crops with improved traits, developing biosensors for environmental monitoring, and designing computational models for predictive biology. The integration of machine learning and automation technologies with oligonucleotide synthesis workflows holds the potential to accelerate innovation and streamline the design-build-test cycle in synthetic biology research and development.
Competitive Landscape Analysis
Key players in Global Oligonucleotide Synthesis Market include:
- Danaher Corporation (US)
- Thermo Fisher Scientific Inc. (US)
- Merck KGaA (Germany)
- Eurofins Scientific (Luxembourg)
- LGC Limited (UK)
- Agilent Technologies, Inc. (US)
- Kaneka Corporation (Japan)
- Maravai Lifesciences Holdings, Inc. (US)
- Azenta, Inc. (US)
In this report, the profile of each market player provides following information:
- Company Overview and Product Portfolio
- Key Developments
- Financial Overview
- Strategies
- Company SWOT Analysis
- Introduction
- Research Objectives and Assumptions
- Research Methodology
- Abbreviations
- Market Definition & Study Scope
- Executive Summary
- Market Snapshot, By Product
- Market Snapshot, By Type
- Market Snapshot, By Region
- Global Oligonucleotide Synthesis Market Dynamics
- Drivers, Restraints and Opportunities
- Drivers
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Advancements in Biotechnology and Genomics
-
Growing Demand for Personalized Medicine
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Increasing Prevalence of Genetic Disorders and Chronic Diseases
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- Restraints
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High Cost of Oligonucleotide Synthesis
-
Stringent Regulatory Requirements
-
Limited Adoption in Developing Regions
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- Opportunities
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Rising Investment in Oligonucleotide-Based Therapies
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Technological Innovations in Synthesis Processes
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Expansion of Synthetic Biology and Genome Editing Applications
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- Drivers
- PEST Analysis
- Political Analysis
- Economic Analysis
- Social Analysis
- Technological Analysis
- Porter's Analysis
- Bargaining Power of Suppliers
- Bargaining Power of Buyers
- Threat of Substitutes
- Threat of New Entrants
- Competitive Rivalry
- Drivers, Restraints and Opportunities
- Market Segmentation
- Global Oligonucleotide Synthesis Market, By Product, 2020 - 2030 (USD Million)
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Drugs
-
Synthesized Oligo
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Reagents
-
Equipment
-
- Global Oligonucleotide Synthesis Market, By Type, 2020 - 2030 (USD Million)
-
Custom
-
Predesigned
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- Global Oligonucleotide Synthesis Market, By Geography, 2020 - 2030 (USD Million)
- North America
- United States
- Canada
- Europe
- Germany
- United Kingdom
- France
- Italy
- Spain
- Nordic
- Benelux
- Rest of Europe
- Asia Pacific
- Japan
- China
- India
- Australia & New Zealand
- South Korea
- ASEAN (Association of South East Asian Countries)
- Rest of Asia Pacific
- Middle East & Africa
- GCC
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- North America
- Global Oligonucleotide Synthesis Market, By Product, 2020 - 2030 (USD Million)
- Competitive Landscape
- Company Profiles
- Danaher Corporation (US)
- Thermo Fisher Scientific Inc. (US)
- Merck KGaA (Germany)
- Eurofins Scientific (Luxembourg)
- LGC Limited (UK)
- Agilent Technologies, Inc. (US)
- Kaneka Corporation (Japan)
- Maravai Lifesciences Holdings, Inc. (US)
- Azenta, Inc. (US)
- Company Profiles
- Analyst Views
- Future Outlook of the Market
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